ArticleAmerican journal of physiology. Cell physiology2019
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.
Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Transposon expression and repression in skeletal muscle.Mobile DNA · 2025Review
- DNA Methylation in the Adaptive Response to Exercise.Sports medicine (Auckland, N.Z.) · 2024Review
- Comprehensive analysis of the expression patterns and function of theFrontiers in veterinary science · 2024Article
- Convergence of signaling pathways in mediating actions of leucine and IGF-1 on mTORC1 in L6 myoblasts.American journal of physiology. Cell physiology · 2022Article
- Transposable element landscapes in aging Drosophila.PLoS genetics · 2022Article
- A Theacrine-Based Supplement Increases Cellular NADNutrients · 2020Article
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Authors and funding
13 authors.
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Abstract
Transposable elements (TEs) are mobile DNA and constitute approximately half of the human genome. LINE-1 (L1) is the only active autonomous TE in the mammalian genome and has been implicated in a number of diseases as well as aging. We have previously reported that skeletal muscle L1 expression is lower following acute and chronic exercise training in humans. Herein, we used a rodent model of voluntary wheel running to determine whether long-term exercise training affects markers of skeletal muscle L1 regulation. Selectively bred high-running female Wistar rats (
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