Evidence map›Paper›PMID 31618063›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-κB kinase subunit β-dependent atherosclerosis in pulmonary arteries.

Toshihiro Imamura, Jin Xue, Orit Poulsen, Dan Zhou, Michael Karin, Gabriel G Haddad

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. A longitudinalCardiovascular diagnosis and therapy · 2021
    Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Toshihiro ImamuraDepartment of Pediatrics, Division of Respiratory Medicine, University of California San Diego School of Medicine, La Jolla, California.ORCID 0000-0002-9804-4583
Jin XueDepartment of Pediatrics, Division of Respiratory Medicine, University of California San Diego School of Medicine, La Jolla, California.
Orit PoulsenDepartment of Pediatrics, Division of Respiratory Medicine, University of California San Diego School of Medicine, La Jolla, California.
Dan ZhouDepartment of Pediatrics, Division of Respiratory Medicine, University of California San Diego School of Medicine, La Jolla, California.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California.
Gabriel G HaddadDepartment of Pediatrics, Division of Respiratory Medicine, University of California San Diego School of Medicine, La Jolla, California.
University of California San Diego · US

Funding

NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of InflammationR37AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin · 2018 to 2026
$6.0M
NIAID NIH HHS R37 AI043477
6 · The paper itself

Abstract

Clinical studies have shown that obstructive sleep apnea (OSA) increases atherosclerosis risk. The inflammation, especially mediated by the macrophages via nuclear factor-κB (NF-κB), has been speculated to contribute to atherogenicity in OSA patients. Inhibitor of NF-κB kinase-β (IKKβ) is an essential element of the NF-κB pathway and is linked to atherosclerosis. We previously reported that atherosclerosis was accelerated in pulmonary artery (PA) but not in aorta when low-density lipoprotein receptor knockout (

Indexed as

AnimalsAtherosclerosisCarbon DioxideCholesterolGene Expression RegulationHypercapniaHypoxiaI-kappa B KinaseMiceMice, KnockoutNF-kappaB-Inducing KinaseOxygenProtein Serine-Threonine KinasesPulmonary ArteryReceptors, LDLWeight GainCarbon DioxideCholesterolI-kappa B KinaseIkbkb protein, mouseNF-kappaB-Inducing KinaseOxygenProtein Serine-Threonine KinasesReceptors, LDLatherosclerosisintermittent hypoxia and hypercapnianuclear factor-κBobstructive sleep apneapulmonary artery

Identifiers

PMID31618063
PMCPMC6962627
OpenAlexW2980961941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.