Observational studyRadiology2019
Relationship between Lower Dose and Injection Speed of Iodinated Contrast Material for CT and Acute Hypersensitivity Reactions: An Observational Study.
Observational study in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictors of acute adverse reactions to non-ionic iodinated contrast media in CT imaging: a systematic review and meta-analysis.Frontiers in radiology · 2025Pooled it
- Shortage of iodinated contrast media: Status and possible chances - A systematic review.European journal of radiology · 2023Pooled it
- A randomised controlled trial comparing three clinical administration strategies in spectral detector CT pulmonary angiography with low contrast medium dose.European radiology · 2025Trial
- Feasibility study of 'Triple-Low' technique for coronary artery computed tomography angiography (CCTA).Scientific reports · 2024Trial
- Renal protection CT protocol using low-dose and low-concentration iodine contrast medium in at-risk patients of HCC and with chronic kidney disease: a randomized controlled non-inferiority trial.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Trial
- Low-contrast-dose liver CT using low monoenergetic images with deep learning-based denoising for assessing hepatocellular carcinoma: a randomized controlled noninferiority trial.European radiology · 2023Trial
- Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement.The World Allergy Organization journal · 2026Review
- Deep Learning Algorithm-Reconstructed Triple-Rule-Out CT: Image Quality and Performance in Evaluating Coronary Lumen Stenosis.Journal of imaging informatics in medicine · 2026Article
- Optimization of the Contrast Concentration for Low-Tube-Voltage Chest CT: A Randomized Controlled Trial with Low-Concentration Contrast Media.Diagnostics (Basel, Switzerland) · 2025Article
- Machine Learning Model to Predict Iodine Contrast Media-Related Acute Adverse Reaction in Patients Without a Similar History for Enhanced CT.Current medical imaging · 2025Article
- Risk factor analysis of iodinated contrast medium-related hypersensitivity reactions.Insights into imaging · 2025Review
- Are we systematically overdosing women? Revisiting standardized contrast protocols for thoracoabdominal CT scans.European radiology · 2025Article
- Achieving low radiation dose and contrast agents dose in coronary CT angiography at 60-kVp ultra-low tube voltage.BMC medical imaging · 2025Article
- Hypersensitivity reactions to iodinated contrast media: potential mechanisms and clinical management.Frontiers in medicine · 2025Review
- Comparative Safety Profiles and Usage Patterns of Iodinated Contrast Media in Medical Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- Deep Learning Denoising Improves CT Perfusion Image Quality in the Setting of Lower Contrast Dosing: A Feasibility Study.AJNR. American journal of neuroradiology · 2024Article
- Drug provocation tests (DPTs) of contrast media: Useful or not useful? - A narrative review.The World Allergy Organization journal · 2024Review
- Non-invasive fast assessment of hepatic injury through computed tomography imaging with renal-clearable Bi-DTPA dimeglumine.Regenerative biomaterials · 2024Article
- Contrast-induced anaphylaxis: does it occur in the medical environment and is it being responded to appropriately?Japanese journal of radiology · 2023Article
- Magnetically assisted soft milli-tools for occluded lumen morphology detection.Science advances · 2023Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundThere are few data on the relationship between acute hypersensitivity reactions and the dose and injection rate of iodinated contrast material for CT.PurposeTo determine the relationship between lower dose and injection speed of iodinated contrast material for CT and the rate of acute hypersensitivity reactions.Materials and MethodsThis retrospective study included adults (age ≥18 years) undergoing nonionic iodinated contrast material-enhanced abdominal CT between August 2016 and January 2017 (control period) and between August 2017 and January 2018 (intervention period); all examinations were conducted in an outpatient setting. Compared with CT during the control period, CT during the intervention period involved a reduced dose of contrast material achieved by lowering the CT tube voltage. CT examinations in the control period were performed with 120 kVp, a contrast material dose of 2 mL/kg (maximum, 150 mL), and an injection speed of 3 or 4 mL/sec. CT examinations in the intervention period were performed with 100 kVp, a contrast material dose of 1.5 mL/kg (maximum, 130 mL), and an injection speed of 2.5 or 3 mL/sec. Per-examination rates of acute hypersensitivity reactions to iodinated contrast material were compared between the control and intervention periods with use of a multivariable Poisson regression model, the parameters of which were estimated by using generalized estimating equations with an independence correlation structure.ResultsA total of 21947 adults (mean age ± standard deviation, 59 years ± 12; 8797 women [40%]) underwent 25119 CT examinations during the control period; 23019 adults (mean age, 59 years ± 12; 9538 women [41%]) underwent 26491 CT examinations during the intervention period. The rate of acute hypersensitivity reactions was 1.42% (376 of 26491 examinations; 95% confidence interval [CI]: 1.28%, 1.57%) in the intervention period and 1.86% (468 of 25119 examinations; 95% CI: 1.70%, 2.04%) in the control period, with a multivariable-adjusted relative risk of 0.85 (95% CI: 0.74, 0.99;
Indexed as
Identifiers
31617789What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.