Evidence map›Paper›PMID 31617425›Full record

Observational studyThe Journal of international medical research2020

Comparison of FRAX in postmenopausal Asian women with and without type 2 diabetes mellitus: a retrospective observational study.

Chen Wang, Jun Liu, Li Xiao, Dan Liu, Wenjing Yan, Ting Hu, Kunhong Li, Xiaociao Hua, Xianshang Zeng

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Effect of Type 2 Diabetes on Bone Quality: A Systematic Review and Meta-Analysis of Cohort Studies.International journal of environmental research and public health · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen WangDepartment of Anesthesiology, Pu'ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 76 Jiefang Avenue, Qiaokou District, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0003-2322-5758
Jun LiuDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Yuexiu District, Guangzhou, China.
Li XiaoDepartment of Gynaecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26, Shengli Street, Wuhan, Hubei, China.
Dan LiuDepartment of Internal Medicine, Amcare Primary Care & Out Patient Services Center, Building 3, Anhui Beili Yiyuan, Beiyuan Road, Chaoyang District, Beijing, China.
Wenjing YanOperation Room, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Gusao Shu No. 16, Jiang'an District, Wuhan, China.
Ting HuOperation Room, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Gusao Shu No. 16, Jiang'an District, Wuhan, China.
Kunhong LiDepartment of Anesthesiology, Pu'ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 76 Jiefang Avenue, Qiaokou District, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0003-0333-2150
Xiaociao HuaDepartment of Anesthesiology, The Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, No. 56, Lingyuan West Road, Guangzhou, China.
Xianshang ZengDepartment of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Yuexiu District, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the fracture risk in postmenopausal Asian women with or without type 2 diabetes mellitus (T2DM).

methodsThe study cohort comprised data from consecutive postmenopausal women with T2DM that were retrieved from a prospectively maintained institutional database from 2001 to 2009. Postmenopausal women without DM from the Medical Examination Center from 2001 to 2009 formed the control cohort. The primary endpoint was the World Health Organization Fracture Risk Algorithm (FRAX, revised 2013) score. The secondary endpoint was bone mineral density (BMD).

resultsThere were 1014 individuals included for the assessment (T2DM, n=500 and non-DM, n=514). Based on the FRAX model, the risk of major osteoporotic fractures and hip fractures over the next 10 years was higher in the T2DM group compared with the non-DM group. Compared with the T2DM group, the non-DM group had a lower BMD. After adjusting for age, gender, history of alcohol consumption, smoking status, body mass index, and low-density lipoprotein, the differences were statistically significant.

conclusionsCompared with postmenopausal women without DM, postmenopausal women with T2DM had a significantly higher fracture risk calculated using the FRAX model. Early intervention for postmenopausal women with T2DM may be necessary, although T2DM is associated with a high BMD.

Indexed as

Diabetes Mellitus, Type 2Osteoporosis, PostmenopausalOsteoporotic FracturesRisk FactorsAgedBone DensityFemaleHumansMiddle AgedPostmenopauseRisk Assessmentbone mineral densityDiabetes mellitusfracture risk assessment toolFRAXhip fractureosteoporosisosteoporotic fracturepostmenopausal

Identifiers

PMID31617425
PMCPMC7783259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.