Evidence map›Paper›PMID 31617381›Full record

ArticleAIDS research and human retroviruses2020

Systemic Mitochondrial Oxidative Phosphorylation Protein Levels Correlate with Neuroimaging Measures in Chronically HIV-Infected Individuals.

Kalpana J Kallianpur, Maegen Walker, Mariana Gerschenson, Cecilia M Shikuma, Louie Mar A Gangcuangco, Lindsay Kohorn, Daniel E Libutti, Talia M Nir, Neda Jahanshad, Paul M Thompson and 1 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kalpana J KallianpurHawaii Center for AIDS, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Maegen WalkerHawaii Center for AIDS, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Mariana GerschensonDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Cecilia M ShikumaHawaii Center for AIDS, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Louie Mar A GangcuangcoHawaii Center for AIDS, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Lindsay KohornHawaii Center for AIDS, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Daniel E LibuttiDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Talia M NirImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck USC School of Medicine, Marina del Rey, California.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck USC School of Medicine, Marina del Rey, California.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck USC School of Medicine, Marina del Rey, California.
Robert PaulMissouri Institute of Mental Health, University of Missouri, St. Louis, Missouri.
University of Hawaiʻi at Mānoa · USMarina Del Rey Hospital · USMissouri Institute of Mental Health · US

Funding

The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Role of Oxidative Stress and Inflammation in HIV Cardiovascular RiskR01HL095135 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI SHIKUMA, CECILIA M. · 2008 to 2012
$4.5M
High resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1M
Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s DiseaseT32AG058507 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2018 to 2026
$2.1M
NHLBI NIH HHS R01 HL095135NIA NIH HHS R01 AG059874NIA NIH HHS T32 AG058507NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM113134NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Few studies have examined systemic mitochondrial function in conjunction with brain imaging in human immunodeficiency virus (HIV) disease. Oxidative phosphorylation enzyme protein levels of peripheral blood mononuclear cells were measured in association with neuroimaging indices in 28 HIV+ individuals. T1-weighted magnetic resonance imaging yielded volumes of seven brain regions of interest; diffusion tensor imaging determined fractional anisotropy (FA) and mean diffusivity (MD) in the corpus callosum (CC). Higher nicotinamide adenine dinucleotide dehydrogenase levels correlated with lower volumes of thalamus (

Indexed as

NeuroimagingOxidative PhosphorylationBrainCross-Sectional StudiesDiffusion Magnetic Resonance ImagingElectron Transport Complex IVFemaleHIV InfectionsHumansLeukocytes, MononuclearLongitudinal StudiesMaleMiddle AgedMitochondriaMitochondrial ProteinsOrgan SizeElectron Transport Complex IVMitochondrial ProteinsOxidoreductasesbrainHIVmitochondriaoxidative phosphorylationoxidative stress

Identifiers

PMID31617381
PMCPMC6944134
OpenAlexW2980820048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.