Evidence map›Paper›PMID 31617300›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Electrostatic Complementarity Drives Amyloid/Nucleic Acid Co-Assembly.

Allisandra K Rha, Dibyendu Das, Olga Taran, Yonggang Ke, Anil K Mehta, David G Lynn

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The Evolution of Functional Amyloids and Their Impact on Host-Microbe Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
  12. Supramolecular Architectures of Nucleic Acid/Peptide Hybrids.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Allisandra K RhaChemistry and Biology, Emory University, 1521 Dickey Drive NE, Atlanta, GA, 30322, USA.ORCID 0000-0003-1299-1748
Dibyendu DasChemistry and Biology, Emory University, 1521 Dickey Drive NE, Atlanta, GA, 30322, USA.ORCID 0000-0001-6597-8454
Olga TaranChemistry and Biology, Emory University, 1521 Dickey Drive NE, Atlanta, GA, 30322, USA.ORCID 0000-0003-1994-0847
Yonggang KeBiomedical Engineering, Emory and Georgia Institute of Technology, Atlanta, GA, 30322, USA.ORCID 0000-0003-1673-2153
Anil K MehtaChemistry and Biology, Emory University, 1521 Dickey Drive NE, Atlanta, GA, 30322, USA.ORCID 0000-0002-9867-151X
David G LynnChemistry and Biology, Emory University, 1521 Dickey Drive NE, Atlanta, GA, 30322, USA.ORCID 0000-0003-2200-059X
Emory University · USGeorgia Institute of Technology · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2005 to 2019
$25.7M
Division of Materials Research NSF/DMR-BSF 1610377National Science Foundation CHE-1507932NIA NIH HHS P50 AG025688NIA NIH HHS P50AG025688NIH HHS P51 OD011132
6 · The paper itself

Abstract

Proteinaceous plaques associated with neurodegenerative diseases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids. Polyanion-induced amyloid fibrillation has been implicated in disease etiology, but structural models for amyloid/nucleic acid co-assemblies remain limited. Here we constrain nucleic acid/peptide interactions with model peptides that exploit electrostatic complementarity and define a novel amyloid/nucleic acid co-assembly. The structure provides a model for nucleic acid/amyloid co-assembly as well as insight into the energetic determinants involved in templating amyloid assembly.

Indexed as

AmyloidHumansModels, MolecularPeptide Nucleic AcidsStatic ElectricityAmyloidPeptide Nucleic AcidsAlzheimer's diseasebiopolymersnucleic acid/amyloid co-assemblysolid-state NMR spectroscopy

Identifiers

PMID31617300
PMCPMC6923580
OpenAlexW2980585105

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.