Evidence map›Paper›PMID 31617299›Full record

ArticlePediatric transplantation2020

Fecal microbiota transplantation in a toddler after heart transplant was a safe and effective treatment for recurrent Clostridiodes difficile infection: A case report.

Joseph A Spinner, Claire E Bocchini, Ruth A Luna, Santosh Thapa, Miriam A Balderas, Susan W Denfield, William J Dreyer, Dorottya Nagy-Szakal, Faith D Ihekweazu, James Versalovic and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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  8. [Advances in the treatment ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Joseph A SpinnerSection of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9539-6252
Claire E BocchiniSection of Pediatric Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Ruth A LunaDepartment of Pathology and Immunology, Texas Children's Microbiome Center, Baylor College of Medicine, Houston, TX, USA.
Santosh ThapaDepartment of Pathology and Immunology, Texas Children's Microbiome Center, Baylor College of Medicine, Houston, TX, USA.
Miriam A BalderasDepartment of Pathology and Immunology, Texas Children's Microbiome Center, Baylor College of Medicine, Houston, TX, USA.
Susan W DenfieldSection of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
William J DreyerSection of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Dorottya Nagy-SzakalSection of Pediatric Gastroenterology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Faith D IhekweazuSection of Pediatric Gastroenterology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
James VersalovicDepartment of Pathology and Immunology, Texas Children's Microbiome Center, Baylor College of Medicine, Houston, TX, USA.
Tor SavidgeDepartment of Pathology and Immunology, Texas Children's Microbiome Center, Baylor College of Medicine, Houston, TX, USA.
Richard KellermayerSection of Pediatric Gastroenterology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · US

Funding

Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9M
NIAID NIH HHS U01 AI124290NIH HHS U01-AI24290
6 · The paper itself

Abstract

Pediatric recipients of SOT have a significantly increased risk of Clostridiodes (formerly Clostridium) difficile infection (CDI), which is associated with adverse outcomes after SOT. Alterations to the intestinal microbiota community structure increase the risk of CDI. FMT is a safe and effective treatment for recurrent CDI in immunocompetent children and adults. While there are increasing data that FMT in immunosuppressed patients is safe and effective without increased risk of infection, data regarding safety and efficacy of FMT in children after SOT are limited. To our knowledge, we report the youngest immunocompromised patient to undergo FMT and the third overall case of FMT in a child after HTx. Our patient presented with five episodes of rCDI in 6 months, and 16S rRNA genetic analysis revealed significant loss of overall microbiota community structure and diversity prior to FMT compared with a donor and a healthy, age-matched control. After FMT, marked and prolonged (at least 16 months) shifts in the recipient microbiota community structure and diversity were evident, approaching that of donor and healthy, age-matched control. FMT was well tolerated, restored microbial diversity without any graft or transplant complications, and prevented further rCDI episodes after more than 4 years of follow-up.

Indexed as

Clostridioides difficileFecal Microbiota TransplantationHeart TransplantationImmunocompromised HostChild, PreschoolClostridium InfectionsFemaleHumansPostoperative ComplicationsRecurrenceClostridium difficilefecal microbiota transplantpediatric heart transplant

Identifiers

PMID31617299
PMCPMC6982574
OpenAlexW2980479310

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.