Evidence map›Paper›PMID 31617281›Full record

ArticleHuman brain mapping2020

The role of BDNF methylation and Val

Ronny Redlich, Ilona Schneider, Nicole Kerkenberg, Nils Opel, Jonas Bauhaus, Verena Enneking, Jonathan Repple, Elisabeth J Leehr, Dominik Grotegerd, Claas Kähler and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. The role of BDNF methylation and ValHuman brain mapping · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 2 countries.

Ronny RedlichDepartment of Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0002-7018-4525
Ilona SchneiderDepartment of Psychiatry, University of Münster, Münster, Germany.
Nicole KerkenbergDepartment of Psychiatry, University of Münster, Münster, Germany.
Nils OpelDepartment of Psychiatry, University of Münster, Münster, Germany.
Jonas BauhausDepartment of Psychiatry, University of Münster, Münster, Germany.
Verena EnnekingDepartment of Psychiatry, University of Münster, Münster, Germany.
Jonathan ReppleDepartment of Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0003-1379-9491
Elisabeth J LeehrDepartment of Psychiatry, University of Münster, Münster, Germany.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Claas KählerDepartment of Psychiatry, University of Münster, Münster, Germany.
Katharina FörsterDepartment of Psychiatry, University of Münster, Münster, Germany.
Katharina DohmDepartment of Psychiatry, University of Münster, Münster, Germany.
Susanne MeinertDepartment of Psychiatry, University of Münster, Münster, Germany.
Tim HahnDepartment of Psychiatry, University of Münster, Münster, Germany.
Harald KugelDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Kathrin SchwarteDepartment of Psychiatry, University of Münster, Münster, Germany.
Christiane SchettlerDepartment of Psychiatry, University of Münster, Münster, Germany.
Katharina DomschkeDepartment of Psychiatry, University of Münster, Münster, Germany.
Volker AroltDepartment of Psychiatry, University of Münster, Münster, Germany.
Walter HeindelDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Weiqi ZhangDepartment of Psychiatry, University of Münster, Münster, Germany.
Christa HohoffDepartment of Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
University of Münster · DEThe University of Melbourne · AUUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene have been associated with psychiatric disorders in humans and with differences in amygdala BDNF mRNA levels in rodents. This human study aimed to investigate the relationship between the functional BDNF-Val

Indexed as

DNA MethylationAdultAmygdalaBrain-Derived Neurotrophic FactorEmotionsEpigenesis, GeneticFacial RecognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPersonalityPolymorphism, GeneticPsychomotor PerformanceYoung AdultBDNF protein, humanBrain-Derived Neurotrophic Factoramygdala reactivityBDNFfMRImethylationnovelty seekingVal66Met

Identifiers

PMID31617281
PMCPMC7268057
OpenAlexW2981199459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.