SynthesisInternational journal of geriatric psychiatry2020
Empirical support for the vascular apathy hypothesis: A structured review.
Synthesis in International journal of geriatric psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Vascular disease and apathy symptoms in the very old: A cross-sectional and longitudinal meta-analysis of individual participant data.International journal of geriatric psychiatry · 2022Pooled it
- Empirical support for the vascular apathy hypothesis: A structured review.International journal of geriatric psychiatry · 2020Pooled it
- Cerebral small vessel disease: pearls and pitfalls from unexplored risk factors to treatment.Arquivos de neuro-psiquiatria · 2026Review
- Clinical Associations and Possible Risk Factors for Affective Neuropsychiatric Symptoms in Older Adults With and Without Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Under pressure: A systematic review of the association between blood pressure variability with depression and anxiety.Cerebral circulation - cognition and behavior · 2024Article
- Vascular cognitive impairment: When memory loss is not the biggest challenge.Dementia (London, England) · 2024Article
- Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in neurocognitive disorders.International journal of geriatric psychiatry · 2023Review
- The Synergic Effect of AT(N) Profiles and Depression on the Risk of Conversion to Dementia in Patients with Mild Cognitive Impairment.International journal of molecular sciences · 2023Article
- The relevance of the socio-emotional deficits in cerebral small vessels disease (CSVD): An exploratory study with sporadic CSVD and CADASIL patients.Cerebral circulation - cognition and behavior · 2023Article
- Visit-To-Visit Blood Pressure Variability and Subthreshold Depressive Symptoms in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Detecting apathy in patients with cerebral small vessel disease.Frontiers in aging neuroscience · 2022Article
- Pathomechanisms of Vascular Depression in Older Adults.International journal of molecular sciences · 2021Review
- Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making.Brain : a journal of neurology · 2021Article
- Diagnosis and Assessment of Apathy in Elderly Chinese Patients With Cerebral Small Vessel Disease.Frontiers in psychiatry · 2021Article
- Predicting the Emergence of Major Neurocognitive Disorder Within Three Months After a Stroke.Frontiers in aging neuroscience · 2021Article
- Affective Neuropsychiatric Symptoms as Early Signs of Dementia Risk in Older Adults.Journal of Alzheimer's disease : JAD · 2020Article
- Social isolation and subclinical vascular pathways to cerebrovascular disease.Biodemography and social biologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA systematic review of the relationship between subclinical small vessel disease (SSVD) in the general population and apathy to examine the hypothesis that apathy has a vascular basis.
methodsWe searched for studies on associations between apathy and SSVD, operationalized as white matter hyperintensities (WMH) or white matter diffusivity changes, lacunar infarcts, cerebral microbleeds, decreasing cortical thickness, and perivascular spaces, while also peripheral proxies for SSVD were considered, operationalized as ankle brachial pressure index (ABI), intima media thickness, arterial stiffness, cardio-femoral pulse wave velocity, hypertension, or cardiovascular disease. Only eligible retrospective and prospective observational studies conducted in the general population were included.
resultsThe 14 studies eligible for review examined the associations between apathy and hypertension (3), ABI (1), arterial stiffness (1), cardiovascular disease (2), WMH (3), white matter diffusivity (2), cerebral microbleeds (1), or cortical thickness (3). Arterial stiffness and white matter diffusivity were not related to apathy, while the associations with cortical thickness were contradictory. Cross-sectional studies in the general population did find evidence of apathy being associated with WMH, CM, cardiovascular disease, hypertension, and ABI, and cardiovascular disease was prospectively associated with apathy. The methodologies of the studies reviewed were too heterogeneous to perform meta-analyses.
conclusionsAlthough more prospective evidence is needed and vascular depression needs to be controlled for, cardiovascular disease, hypertension, and ABI as proxies for SSVD, and WMH and cerebral microbleeds as direct measures of SSVD have been found to be associated with apathy in the general population, supporting the hypothesis of vascular apathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.