Evidence map›Paper›PMID 31617145›Full record

ArticlePlant molecular biology2019

Negative regulation of cadmium tolerance in Arabidopsis by MMDH2.

Xi Wu, Yangyang Han, Xiangyu Zhu, Alia Shah, Wei Wang, Yibao Sheng, Tingting Fan, Shuqing Cao

Abstract read
PubMed Publisher
In one paragraph

Article in Plant molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Encoded CPlant signaling & behavior · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xi WuEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Yangyang HanEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Xiangyu ZhuEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Alia ShahEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Wei WangEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Yibao ShengEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Tingting FanEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Shuqing CaoEngineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China. shuqingcao@hfut.edu.cn.
Hefei University of Technology · CN

Funding

National Natural Science Foundation of China 31571250National Natural Science Foundation of China 31770284National Natural Science Foundation of China 31872803
6 · The paper itself

Abstract

key messageMMDH2 gene negatively regulates Cd tolerance by modulating reactive oxygen species (ROS) levels and the ROS-mediated signaling, thus, affecting the expression of PDR8. The molecular mechanism by which plants respond to stress caused by cadmium (Cd), one of the most toxic heavy metals to plants, is not well understood. Here, we show that MMDH2, a gene encoding mitochondrial malate dehydrogenase, is involved in Cd stress tolerance in Arabidopsis. The expression of MMDH2 was repressed by Cd stress. The mmdh2 knockdown mutants showed enhanced Cd tolerance, while the MMDH2-overexpressing lines were sensitive to Cd. Under normal and Cd stress conditions, lower H

Indexed as

Amino Acid SequenceArabidopsisArabidopsis ProteinsATP-Binding Cassette TransportersCadmiumGene Expression Regulation, PlantGene Knockdown TechniquesHydrogen PeroxideMalate DehydrogenaseModels, BiologicalReactive Oxygen SpeciesSequence AlignmentSignal TransductionStress, PhysiologicalArabidopsis ProteinsAT3G15020 protein, ArabidopsisATP-Binding Cassette TransportersCadmiumHydrogen PeroxideMalate DehydrogenasePDR8 protein, ArabidopsisReactive Oxygen SpeciesCadmiumMMDH2PDR8Reactive oxygen species

Identifiers

PMID31617145
OpenAlexW2981274708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.