Evidence map›Paper›PMID 31617114›Full record

ArticleObesity surgery2020

Resting Energy Expenditure and Organ-Tissue Body Composition 5 Years After Bariatric Surgery.

Stanley Heshka, Thaisa Lemos, Nerys M Astbury, Elizabeth Widen, Lance Davidson, Bret H Goodpaster, James P DeLany, Gladys W Strain, Alfons Pomp, Anita P Courcoulas and 6 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00465829 (Longitudinal Assessment of Bariatric Surgery), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00465829 completednot on this map

Longitudinal Assessment of Bariatric Surgery (LABS-2)

TypeobservationalSponsorUniversity of PittsburghRan2006 to 2016Enrolled2,458ConditionsObesity
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Obese Women.International journal of environmental research and public health · 2022
    Trial
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  9. Understanding Impact of Anti-Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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  11. Article
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Stanley HeshkaDepartment of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Thaisa LemosDepartment of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Nerys M AstburyDepartment of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Elizabeth WidenDepartment of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA.
Lance DavidsonDepartment of Exercise Sciences, Brigham Young University, Provo, UT, USA.
Bret H GoodpasterTranslational Research Institute for Metabolism and Diabetes, Orlando, FL, USA.
James P DeLanyTranslational Research Institute for Metabolism and Diabetes, Orlando, FL, USA.
Gladys W StrainGI Metabolic and Bariatric Surgery, Weill Cornell Medicine, New York, NY, USA.
Alfons PompGI Metabolic and Bariatric Surgery, Weill Cornell Medicine, New York, NY, USA.
Anita P CourcoulasGeneral Surgery, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Susan LinCenter for Family and Community Medicine, Columbia University Medical Center, New York, NY, USA.
Isaiah JanumalaDepartment of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Wen YuDepartment of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Patrick KangNew York Radiology Partners, New York, NY, USA.
John C ThorntonThornton Consulting, Mahopac, NY, USA.
Dympna GallagherDepartment of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA. dg108@columbia.edu.ORCID 0000-0003-1769-9754
Columbia University Irving Medical Center · USCornell University · USTranslational Research Institute for Metabolism and Diabetes · USBrigham Young University · USNational Audubon Society · USThe University of Texas at Austin · USThornton Tomasetti (United States) · USUniversity of Pittsburgh · US

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Predictors of Recidivism to Obesity in Weight-Reduced IndividualsUH3DK128302 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DYMPNA GALLAGHER, RUDOLPH L LEIBEL · 2022 to 2026
$7.0M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Body Composition &REE Responses to Bariatric SurgeriesR01DK072507 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI GALLAGHER, DYMPNA · 2005 to 2015
$4.8M
OBESITY RESEARCH CENTER TRAINING PROGRAMT32DK007559 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI DYMPNA GALLAGHER · 1989 to 2026
$4.3M
NICHD NIH HHS P2C HD042849NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R01 DK072507NIDDK NIH HHS T32 DK007559NIDDK NIH HHS UH3 DK128302
6 · The paper itself

Abstract

introductionBariatric surgery-induced weight loss may reduce resting energy expenditure (REE) and fat-free mass (FFM) disproportionately thereby predisposing patients to weight regain and sarcopenia.

methodsWe compared REE and body composition of African-American and Caucasian Roux-en-Y gastric bypass (RYGB) patients after surgery with a group of non-operated controls (CON). REE by indirect calorimetry; skeletal muscle (SM), trunk organs, and brain volumes by MRI; and FFM by DXA were measured at post-surgery visits and compared with CON (N = 84) using linear regression models that adjusted for relevant covariates. Ns in RYGB were 50, 42, and 30 for anthropometry and 39, 27, 17 for MRI body composition at years 1, 2, and 5 after surgery, respectively.

resultsRegression models adjusted for age, weight, height, ethnicity, and sex showed REE differences (RYGB minus CON; mean ± s.e.): year 1 (43.2 ± 34 kcal/day, p = 0.20); year 2 (- 27.9 ± 37.3 kcal/day, p = 0.46); year 5 (114.6 ± 42.3 kcal/day, p = 0.008). Analysis of FFM components showed that RYGB had greater trunk organ mass (~ 0.4 kg) and less SM (~ 1.34 kg) than CON at each visit. REE models adjusted for FFM, SM, trunk organs, and brain mass showed no between-group differences in REE (- 15.9 ± 54.8 kcal/day, p = 0.8; - 46.9 ± 64.9 kcal/day, p = 0.47; 47.7 ± 83.0 kcal/day, p = 0.57, at years 1, 2, and 5, respectively).

conclusionsPost bariatric surgery patients maintain a larger mass of high-metabolic rate trunk organs than non-operated controls of similar anthropometrics. Interpreting REE changes after weight loss requires an accurate understanding of fat-free mass composition at both the organ and tissue levels. CLINICAL

trial registrationLong-term Effects of Bariatric Surgery (LABS-2) NCT00465829.

Indexed as

Bariatric SurgeryAdiposityAdultAgedBasal MetabolismBody CompositionCalorimetry, IndirectCase-Control StudiesEnergy MetabolismFemaleFollow-Up StudiesGastric BypassHumansMaleMiddle AgedObesity, MorbidBariatric surgeryBody compositionBrainFat-free massOrgansResting energy expenditureRoux-en-Y gastric bypassSkeletal muscle

Identifiers

PMID31617114
PMCPMC7103422
OpenAlexW2980598528

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.