ReviewJournal of biomolecular NMR2019
Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins.
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Review in Journal of biomolecular NMR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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Who cites it
27 citing papers in PubMed.
- Embrace Disorder as a Function: Bio-Informed Biomaterials Design Advanced by Intrinsically Disordered Proteins.Biomimetics (Basel, Switzerland) · 2026Article
- Cooperativity, dynamics, and the free-energy surfaces of charge-patterned IDPs.bioRxiv : the preprint server for biology · 2026Article
- Structural Context Modulates the Conformational Ensemble of the Intrinsically Disordered Amino Terminus of α-Synuclein.Journal of the American Chemical Society · 2025Article
- Transient Structural Properties of the Rho GDP-Dissociation Inhibitor.Angewandte Chemie (International ed. in English) · 2024Article
- Molecular Dynamics Simulation and Docking of MUC1 O-Glycopeptide.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Intrinsically disordered regions in TRPV2 mediate protein-protein interactions.Communications biology · 2023Article
- Conformational ensembles explain NMR spectra of frozen intrinsically disordered proteins.Protein science : a publication of the Protein Society · 2023Article
- Interpreting Transient Interactions of Intrinsically Disordered Proteins.The journal of physical chemistry. B · 2023Article
- Disparate viral pandemics from COVID19 to monkeypox and beyond: a simple, effective and universal therapeutic approach hiding in plain sight.Frontiers in immunology · 2023Review
- Structural Studies of Expressed tIK, Anti-Inflammatory Peptide.International journal of molecular sciences · 2022Article
- Lighting up Nobel Prize-winning studies with protein intrinsic disorder.Cellular and molecular life sciences : CMLS · 2022Review
- NMR spectroscopy, excited states and relevance to problems in cell biology - transient pre-nucleation tetramerization of huntingtin and insights into Huntington's disease.Journal of cell science · 2022Article
- Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation.Nucleic acids research · 2022Review
- Intrinsically disordered proteins: Ensembles at the limits of Anfinsen's dogma.Biophysics reviews · 2022Review
- NMR methods for exploring 'dark' states in ligand binding and protein-protein interactions.Progress in nuclear magnetic resonance spectroscopy · 2022Review
- Integrative Conformational Ensembles of Sic1 Using Different Initial Pools and Optimization Methods.Frontiers in molecular biosciences · 2022Article
- Integrative structural dynamics probing of the conformational heterogeneity in synaptosomal-associated protein 25.Cell reports. Physical science · 2021Article
- Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins.RSC chemical biology · 2021Review
- NMR illuminates intrinsic disorder.Current opinion in structural biology · 2021Review
Corrections and comments
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Authors and funding
2 authors.
H Jane DysonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. dyson@scripps.edu.ORCID http://orcid.org/0000-0001-6855-3398
Peter E WrightDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. wright@scripps.edu.ORCID http://orcid.org/0000-0002-1368-0223
Funding
VIRAL DEGENERATIVE DEMENTING DISEASE IN AGING (SUPP)P01AG002132 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRUSINER, STANLEY B · 1985 to 2024
$51.7MUNDERSTANDING AND IMPROVING SMALL MOLECULE INHIBITORS OF PRION REPLICATIONP01AG021601 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRUSINER, STANLEY B · 2003 to 2013
$31.9MSTRUCTURE AND STABILITY OF IKB/NF-KB COMPLEXESP01GM071862 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, GOURISANKAR · 2006 to 2016
$14.9MTUMORICIDAL ACTIVITY OF HOST COMPLEMENTP01CA027489 · NCI · SCRIPPS RESEARCH INSTITUTE · PI LERNER, RICHARD ALAN · 1985 to 2004
$7.7MStructural basis for CBP/p300 transcriptional regulationR01CA096865 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI WRIGHT, PETER EDWIN · 2002 to 2016
$6.2MProtein Dynamics in Dihydrofolate Reductase CatalysisR01GM075995 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI WRIGHT, PETER EDWIN · 2006 to 2021
$6.1MStructural Characterization of Globin Folding PathwaysR01DK034909 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI WRIGHT, PETER EDWIN · 1986 to 2017
$4.8MTRANSGENIC STUDIES OF SCRAPIE "STRAINS" AND CNS DEGENERATION BY MUTANT PRP GENESP50NS014069 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI PRUSINER, STANLEY B · 1994 to 2002
$4.2MUNFOLDED STATES AND FOLDING PATHWAYS BY NMRR01GM057374 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DYSON, HELEN JANE · 1998 to 2011
$3.5MMolecular basis for regulation of CREB by cell stress and retroviral oncoproteinsR01CA214054 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI DENIZ, ASHOK A, WRIGHT, PETER EDWIN · 2017 to 2021
$3.0MStructural Studies of Large Dynamic ComplexesR35GM131693 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DYSON, HELEN JANE · 2019 to 2023
$2.6MMolecular Basis for Regulation of Cellular Stress Response Pathways by CBP/p300R01CA229652 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI WRIGHT, PETER EDWIN · 2018 to 2022
$2.4MNational Institute of Allergy and Infectious Diseases AI19499NCI NIH HHS CA214054NCI NIH HHS CA229652NCI NIH HHS CA27489NCI NIH HHS CA96865NCI NIH HHS P01 CA027489NCI NIH HHS R01 CA096865NCI NIH HHS R01 CA214054NCI NIH HHS R01 CA229652NIAging AG21601NIA NIH HHS P01 AG002132NIA NIH HHS P01 AG021601NIDDK NIH HHS DK34909NIDDK NIH HHS R01 DK034909NIDDK NIH HHS R37 DK034909NIGMS NIH HHS GM075995NIGMS NIH HHS GM113251NIGMS NIH HHS GM38794NIGMS NIH HHS GM56879NIGMS NIH HHS GM57374NIGMS NIH HHS P01 GM056879NIGMS NIH HHS P01 GM071862NIGMS NIH HHS R01 GM057374NIGMS NIH HHS R01 GM075995NIGMS NIH HHS R01 GM113251NIGMS NIH HHS R01 GM127807NIGMS NIH HHS R35 GM131693NINDS NIH HHS NS14069
Abstract
The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered proteins and the development and application of NMR methods to characterize their conformational ensembles, dynamics, and interactions.
Indexed as
AnimalsAwards and PrizesHumansIntrinsically Disordered ProteinsMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein BindingProtein ConformationIntrinsically Disordered ProteinsImmunogenic peptidesIntrinsically disordered proteinsProtein foldingRelaxation dispersion
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