Evidence map›Paper›PMID 31617024›Full record

ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2020

Circulatory microRNAs: promising non-invasive prognostic and diagnostic biomarkers for parasitic infections.

Hossein Ghalehnoei, Abouzar Bagheri, Mahdi Fakhar, Mohammad Amir Mishan

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Review
  10. Review
  11. Review
  12. Review
  13. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hossein GhalehnoeiDepartment of Medical Biotechnology, Toxoplasmosis Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abouzar BagheriDepartment of Clinical Biochemistry-Biophysics and Genetics, Toxoplasmosis Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. a.bagherimg@gmail.com.ORCID http://orcid.org/0000-0001-8040-5056
Mahdi FakharDepartment of Parasitology, Toxoplasmosis Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. mahdif53@yahoo.com.
Mohammad Amir MishanOcular Tissue Engineering Research Center, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a non-coding subclass of endogenous small regulatory RNAs, with about 18-25 nucleotides length which play a critical role in the regulation of gene expression at the post-transcriptional level in eukaryotes. Aberrant expression of miRNAs has the potential to become powerful non-invasive biomarkers in pathological diagnosis and prognosis of different disorders including infectious diseases. Parasite's life cycle may require the ability to respond to environmental and developmental signals through miRNA-mediated gene expressions. Over the last years, thousands of miRNAs have been identified in the helminthic and protozoan parasites and many pieces of evidence have demonstrated the functional role of miRNAs in the parasites' life cycle. Detection of these miRNAs in biofluids of infected hosts as prognostic and diagnostic biomarkers in infectious diseases is growing rapidly. In this review, we have highlighted altered expressions of host miRNAs, detected parasitic miRNAs in the infected hosts, and suggested some perspectives for future studies.

Indexed as

BiomarkersCirculating MicroRNAAnimalsGene Expression RegulationGene Regulatory NetworksHost-Parasite InteractionsHumansMicroRNAsParasitesParasitic DiseasesRNA InterferenceRNA, ProtozoanSpecies SpecificityBiomarkersCirculating MicroRNAMicroRNAsRNA, ProtozoanBiomarkersCirculatory microRNAsDiagnosisParasitic infections

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.