ArticleActa neuropathologica2020
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Acta neuropathologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 105 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer's Disease: A Systematic Review and Meta-analysis.BioMed research international · 2022Pooled it
- From a prion seed to a tree of discoveries: Byron Caughey's RT-QuIC legacy in protein misfolding research.Acta neuropathologica · 2026Review
- Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control.Journal of the American Chemical Society · 2026Article
- Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies.Acta neuropathologica communications · 2026Article
- A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism.Nature medicine · 2026Article
- Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2026Article
- Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha-Synuclein Seed Amplification Assay.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Features of Cross-Seeding of Wild-Type Alpha-Synuclein and Its Mutant Form A53T Potentially Useful for the Development of Test Systems.Life (Basel, Switzerland) · 2026Article
- Dementia in Progressive Supranuclear Palsy: A Narrative Review.Neurology and therapy · 2026Review
- Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Amyloid and Tau Co-pathology in Parkinson Disease and Atypical Parkinsonism.Current neurology and neuroscience reports · 2026Review
- Article
- An eight-year follow-up of the CMSAR: assessing how the new MDS criteria and biomarkers impact diagnostic accuracy.NPJ Parkinson's disease · 2026Article
- From clinical phenotypes to molecular stratification: early differential diagnosis of four-repeat tauopathies.Frontiers in aging neuroscience · 2026Review
- 4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy.Nature communications · 2025Article
- CSF α-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression.Neurology · 2025Article
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- Making tau amyloid models in vitro: a crucial and underestimated challenge.FEBS letters · 2025Review
- Tauopathy strains differentially replicate in vitro in the presence of mutant tau monomer.Neurobiology of disease · 2025Article
- Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau.FEBS letters · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 8 institutions in 3 countries.
Eri SaijoLPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA.
Michael A MetrickLPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA.
Shunsuke KogaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Piero ParchiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139, Bologna, Italy.
Irene LitvanDepartment of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, CA, USA.
Salvatore SpinaMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Adam BoxerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Julio C RojasMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Douglas GalaskoDepartment of Neurosciences, University of California, San Diego, CA, USA.
Allison KrausLPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA.
Marcello RossiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139, Bologna, Italy.
Kathy NewellIndiana University School of Medicine, Indianapolis, IN, USA.
Gianluigi ZanussoUniversity of Verona, Verona, Italy.
Lea T GrinbergMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Bernardino GhettiIndiana University School of Medicine, Indianapolis, IN, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Byron CaugheyLPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA. bcaughey@nih.gov.ORCID 0000-0002-3928-6101
University of California, San Francisco · USIndiana University School of MedicineIstituto delle Scienze Neurologiche di Bologna · ITMayo Clinic in Florida · USUniversity of California San Diego · USRocky Mountain Institute · USUniversidade de São Paulo · BRUniversity of Verona · IT
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MTHE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1MDetection of PrionsZIAAI001086 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$18.1MMultidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4MNeuropathological changes underlying clinical heterogeneity in Alzheimer diseaseK24AG053435 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRINBERG, LEA TENENHOLZ · 2016 to 2025
$1.8MNeuropathological basis of brain network dysfunctionK08AG052648 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINA, SALVATORE · 2016 to 2020
$852kIntramural NIH HHS ZIA AI001086NIA NIH HHS K08 AG052648NIA NIH HHS K24 AG053435NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG010133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG023501NIA NIH HHS T32 AG023481NIH HHS AG05131NIH HHS K24053435
Abstract
To address the need for more meaningful biomarkers of tauopathies, we have developed an ultrasensitive tau seed amplification assay (4R RT-QuIC) for the 4-repeat (4R) tau aggregates of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and other diseases with 4R tauopathy. The assay detected seeds in 10
Indexed as
BiomarkersFluoroimmunoassayFrontotemporal Lobar DegenerationHumansProtein IsoformsSensitivity and Specificitytau ProteinsBiomarkersMAPT protein, humanProtein Isoformstau ProteinsBiomarkerCorticobasal degenerationDiagnosisProgressive supranuclear palsyStrainTau
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.