Evidence map›Paper›PMID 31616929›Full record

ArticleGlycobiology2020

Structural analysis of urinary glycosaminoglycans from healthy human subjects.

Xiaorui Han, Patience Sanderson, Sara Nesheiwat, Lei Lin, Yanlei Yu, Fuming Zhang, I Jonathan Amster, Robert J Linhardt

Abstract read
In one paragraph

Article in Glycobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. ACS central science · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Endogenous Glycosaminoglycans in Various Pathologic Plasma Samples as Measured by a Fluorescent Quenching Method.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaorui HanDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA.
Patience SandersonDepartment of Chemistry, University of Georgia, 140 Cedar St, Athens, GA 30602, USA.
Sara NesheiwatDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA.
Lei LinDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA.
Yanlei YuDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA.
Fuming ZhangDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA.
I Jonathan AmsterDepartment of Chemistry, University of Georgia, 140 Cedar St, Athens, GA 30602, USA.
Robert J LinhardtDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA.

Funding

TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
An Automated Platform for the CE-MS Analysis of GlycosaminoglycansU01CA231074 · NCI · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN · 2018 to 2020
$895k
NCI NIH HHS U01 CA231074NIGMS NIH HHS P41 GM103390NIGMS NIH HHS T32 GM107004
6 · The paper itself

Abstract

Urinary glycosaminoglycans (GAGs) can reflect the health condition of a human being, and the GAGs composition can be directly related to various diseases. In order to effectively utilize such information, a detailed understanding of urinary GAGs in healthy individuals can provide insight into the levels and structures of human urinary GAGs. In this study, urinary GAGs were collected and purified from healthy males and females of adults and young adults. The total creatinine-normalized urinary GAG content, molecular weight distribution and disaccharide compositions were determined. Using capillary zone electrophoresis (CZE)-mass spectrometry (MS) and CZE-MS/MS relying on negative electron transfer dissociation, the major components of healthy human urinary GAGs were determined. The structures of 10 GAG oligosaccharides representing the majority of human urinary GAGs were determined.

Indexed as

AdultCarbohydrate ConformationElectrophoresis, CapillaryFemaleGlycosaminoglycansHealthy VolunteersHumansMaleMass SpectrometryMiddle AgedYoung AdultGlycosaminoglycanscapillary zone electrophoresisglycosaminoglycansmass spectrometrynegative electron transfer dissociationurine

Identifiers

PMID31616929
PMCPMC7415306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.