Evidence map›Paper›PMID 31616809›Full record

ArticleACS omega2019

Conservation of Atypical Allostery in

Nathaniel R Beattie, Nicholas D Keul, Tiffany N Hicks Sirmans, Weston E McDonald, Trevor M Talmadge, Rahil Taujale, Natarajan Kannan, Zachary A Wood

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nathaniel R BeattieDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Nicholas D KeulDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Tiffany N Hicks SirmansDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Weston E McDonaldDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Trevor M TalmadgeDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Rahil TaujaleDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Natarajan KannanDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
Zachary A WoodDepartment of Biochemistry & Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
University of Georgia · US

Funding

The role of intrinsic disorder in the allosteric regulation of human UGDHR01GM114298 · NIGMS · UNIVERSITY OF GEORGIA · PI WOOD, ZACHARY ARTHUR · 2015 to 2025
$2.7M
Functional Annotation of Natural and Disease Variants in Tryosine KinasesR01GM114409 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN · 2015 to 2020
$1.6M
Phase II SER-CAT Optimization: Acquisition of a next generation area detectorS10RR028976 · NCRR · UNIVERSITY OF GEORGIA · PI WANG, BI-CHENG · 2010 to 2010
$1.5M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
Acquition of a microdiffractometer for SER-CATS10RR025528 · NCRR · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2009 to 2009
$414k
Acquisition of an X-ray Generator/Detector System to Support NIH ResearchS10OD021762 · OD · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2016 to 2016
$412k
NCRR NIH HHS S10 RR025528NCRR NIH HHS S10 RR028976NIGMS NIH HHS R01 GM114298NIGMS NIH HHS R01 GM114409NIGMS NIH HHS T32 GM107004NIH HHS S10 OD021762
6 · The paper itself

Abstract

Human UDP-glucose dehydrogenase (hUGDH) oxidizes uridine diphosphate (UDP)-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. The activity of hUGDH is controlled by an atypical allosteric mechanism in which the feedback inhibitor UDP-xylose competes with the substrate for the active site and triggers a buried allosteric switch to produce an inactive complex (E

Identifiers

PMID31616809
PMCPMC6788056
OpenAlexW2977081179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.