ReviewFrontiers in pediatrics2019
Molecular Diagnosis of Allergy: The Pediatric Perspective.
Review in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Inverse association between the molecular spreading of IgE to grass pollen and the IgE response toThe World Allergy Organization journal · 2024Article
- Asthma and Allergy: Unravelling a Tangled Relationship with a Focus on New Biomarkers and Treatment.International journal of molecular sciences · 2022Review
- Article
- Linking cross-reactivity clusters of food and respiratory allergens in PAMD@ to asthma and duration of allergy.The World Allergy Organization journal · 2020Article
- Development of a protein microarray-based diagnostic chip mimicking the skin prick test for allergy diagnosis.Scientific reports · 2020Article
- Digital technologies for an improved management of respiratory allergic diseases: 10 years of clinical studies using an online platform for patients and physicians.Italian journal of pediatrics · 2020Review
- Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View.Children (Basel, Switzerland) · 2020Review
- Microarray-Based Allergy Diagnosis: Quo Vadis?Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In times of "Precision Medicine" it is fundamental to identify the individual disease phenotype in order to provide an individualized therapy for every patient. This concept is also becoming increasingly important for the treatment of allergic diseases. Thanks to the biological engineering of recombinant and native allergens for the assessment of allergen-specific IgE antibodies, it is now possible to easily obtain the individual sensitization profile of a patient. This allows the allergist to precisely identify the primary elicitor of an IgE response and, based on this knowledge, to choose the best treatment option. Several studies have observed the longitudinal evolution of sensitization profiles and identified a phenomenon termed "molecular spreading," which describes a broadening of the recognized allergen spectrum from a source over time. Additionally, the identification of marker proteins, which can trigger an IgE response or correlate with an increased risk for certain clinical symptoms, helps to establish an individual risk profile. This information may not only affect the decision-making concerning immunotherapy, but also opens up avenues for future investigations with regard to prevention strategies. We provide here an overview on the role of individual sensitization patterns and their predictive value.
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Registered trials
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