Evidence map›Paper›PMID 31616565›Full record

ArticleRegenerative biomaterials2019

Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds.

Constantin Edi Tanase, Omar Qutachi, Lisa J White, Kevin M Shakesheff, Andrew W McCaskie, Serena M Best, Ruth E Cameron

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Constantin Edi TanaseDepartment of Materials Science and Metallurgy, University of Cambridge, Cambridge Centre for Medical Materials, Cambridge, 27, Charles Babbage Road, UK.ORCID 0000-0003-1624-4790
Omar QutachiCentre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham, UK.
Lisa J WhiteCentre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham, UK.
Kevin M ShakesheffCentre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham, UK.
Andrew W McCaskieDivision of Trauma & Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, UK.
Serena M BestDepartment of Materials Science and Metallurgy, University of Cambridge, Cambridge Centre for Medical Materials, Cambridge, 27, Charles Babbage Road, UK.
Ruth E CameronDepartment of Materials Science and Metallurgy, University of Cambridge, Cambridge Centre for Medical Materials, Cambridge, 27, Charles Babbage Road, UK.
University of Cambridge · GBUniversity of Nottingham · GB

Funding

Medical Research Council MC_PC_12009Medical Research Council MR/L022893/1
6 · The paper itself

Abstract

Tissue engineering response may be tailored via controlled, sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional (3D) ice-templated collagen scaffolds. However, the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from the incorporated microparticles have not been explored. Here, we load 3D ice-templated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide) microparticles. We probe the effects of subsequent

Indexed as

collagen scaffoldsEDC crosslinkingFITC-BSApercolation diameterPLGA microparticlespore size

Identifiers

PMID31616565
PMCPMC6783698
OpenAlexW2941372337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.