Evidence map›Paper›PMID 31616564›Full record

ArticleRegenerative biomaterials2019

Hyaluronic acid-curcumin conjugate suppresses the fibrotic functions of myofibroblasts from contractive joint by the PTGER2 demethylation.

Dongjie Yu, Ze Zhuang, Jianhua Ren, Xuefeng Hu, Zhe Wang, Jieyu Zhang, Yuansen Luo, Kun Wang, Ronghan He, Yunbing Wang

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Degree-based topological indices and polynomials of hyaluronic acid-curcumin conjugates.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dongjie YuDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ze ZhuangDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jianhua RenDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xuefeng HuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Zhe WangDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jieyu ZhangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Yuansen LuoDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Kun WangDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID 0000-0003-1396-6325
Ronghan HeDepartment of Orthopedic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yunbing WangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Sun Yat-sen University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Joint contracture is a fibrotic complication induced by joint immobilization and trauma, which is characterized as excessive myofibroblast proliferation in joint capsule. The treatments of joint contracture are unsatisfied and patients are suffered from joint dysfunction. Our previous study has shown that curcumin can inhibit myofibroblast proliferation

Indexed as

curcuminjoint contracturemethylationPTGER2

Identifiers

PMID31616564
PMCPMC6783700
OpenAlexW2941725617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.