Evidence map›Paper›PMID 31616441›Full record

ArticleFrontiers in immunology2019

Natural Killer Cells Promote Kidney Graft Rejection Independently of Cyclosporine A Therapy.

Muhammad Imtiaz Ashraf, Attia Sarwar, Anja A Kühl, Elena Hunger, Arne Sattler, Felix Aigner, Heinz Regele, Martina Sauter, Karin Klingel, Stefan Schneeberger and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Chronic histiocytic intervillositis: A breakdown in immune tolerance comparable to allograft rejection?American journal of reproductive immunology (New York, N.Y. : 1989) · 2021
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Muhammad Imtiaz AshrafDepartment of Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Attia SarwarDepartment of General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Anja A KühliPath.Berlin-Immunopathology for Experimental Models, Berlin Institute of Health (BIH), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Elena HungerDepartment of General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Arne SattlerDepartment of General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Felix AignerDepartment of Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Heinz RegeleClinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Martina SauterDepartment of Molecular Pathology, Tübingen University Hospital, Tübingen, Germany.
Karin KlingelDepartment of Molecular Pathology, Tübingen University Hospital, Tübingen, Germany.
Stefan SchneebergerDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Thomas ReschDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Katja KotschDepartment of General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEUniversität Innsbruck · ATUniversity Children's Hospital Tübingen · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural Killer (NK) cells have recently been recognized as key players in antibody-mediated chronic allograft failure, thus requiring a comprehensive understanding whether NK cells can escape conventional immunosuppressive regimens. Influence of cyclosporine A (CyA) on NK cell function was studied in a mouse model of allogeneic kidney transplantation (KTX, BALB/c to C57BL/6). Recipients were treated daily with CyA (10 mg/kg) for seven or 14 days for long term survival (day 56). Administration of CyA in recipients resulted in significantly reduced frequencies of intragraft and splenic CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCyclosporineGraft RejectionGraft SurvivalImmunosuppressive AgentsInterferon-gammaKaplan-Meier EstimateKidney TransplantationKiller Cells, NaturalMaleMice, Inbred BALB CMice, Inbred C57BLTime FactorsTransplantation, HomologousCyclosporineImmunosuppressive AgentsInterferon-gammacyclosporine Agraft rejectionimmunosuppressionkidney transplantationNatural Killer (NK) cells

Identifiers

PMID31616441
PMCPMC6769038
OpenAlexW2975636158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.