Evidence map›Paper›PMID 31616422›Full record

ArticleFrontiers in immunology2019

At Least Two Genes Encode Many Variants of Irak3 in Rainbow Trout, but Neither the Full-Length Factor Nor Its Variants Interfere Directly With the TLR-Mediated Stimulation of Inflammation.

Alexander Rebl, Henrike Rebl, Marieke Verleih, Stephanie Haupt, Judith M Köbis, Tom Goldammer, Hans-Martin Seyfert

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexander ReblFish Genetics Unit, Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Dummerstorf, Germany.
Henrike ReblDepartment of Cell Biology, Rostock University Medical Center, Rostock, Germany.
Marieke VerleihFish Genetics Unit, Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Dummerstorf, Germany.
Stephanie HauptFish Genetics Unit, Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Dummerstorf, Germany.
Judith M KöbisFish Genetics Unit, Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Dummerstorf, Germany.
Tom GoldammerFish Genetics Unit, Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Dummerstorf, Germany.
Hans-Martin SeyfertFish Genetics Unit, Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Dummerstorf, Germany.
Research Institute for Farm Animal Biology (FBN) · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interleukin-1-receptor-associated kinase 3 (IRAK3) is known in mammals as a negative feedback regulator of NF-κB-mediated innate-immune mechanisms. Our RNA-seq experiments revealed a prototypic 1920-nt sequence encoding

Indexed as

AnimalsCell LineFish ProteinsGene Expression RegulationGenetic VariationHEK293 CellsHumansInflammationInterleukin-1betaInterleukin-1 Receptor-Associated KinasesInterleukin-8NF-kappa BOncorhynchus mykissSignal TransductionToll-Like Receptor 2Fish ProteinsInterleukin-1betaInterleukin-1 Receptor-Associated KinasesInterleukin-8NF-kappa BToll-Like Receptor 2CHSE-214GFP expression plasmidIRAK-3salmonid fishesToll-like receptor signaling

Identifiers

PMID31616422
PMCPMC6763605
OpenAlexW2971994631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.