ArticleFrontiers in endocrinology2019
Alteration of Testosterone Levels Changes Brain Wave Activity Patterns and Induces Aggressive Behavior in Rats.
Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- High Doses of N-Acetyl-P-Aminophenol Cause Acute Changes in Electroencephalographic and Electrocardiographic Activities in Wistar Rats.Basic & clinical pharmacology & toxicology · 2026Article
- Testosterone effect on anesthesia depth in micropenis hypospadias surgery: A prospective cohort study.Pakistan journal of medical sciences · 2026Article
- Drug-induced movement disorder: A disproportionality analysis using the FDA adverse event reporting system (FAERS) from 2004 to 2024.PloS one · 2025Article
- Brainwave Patterns and Metabolic Adaptations in Rowers Crossing the Atlantic: A Case Series Pilot Study.Cureus · 2024Article
- Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.PloS one · 2023Article
- 100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats.Endocrine connections · 2022Article
- Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- A Combination ofFrontiers in cellular neuroscience · 2022Article
- Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures.Brain and behavior · 2021Article
- Characterization of electrocorticographic, electromyographic and electrocardiographic recordings after the use of caffeine in Wistar rats.Einstein (Sao Paulo, Brazil) · 2021Article
- Increased Relative Delta Bandpower and Delta Indices Revealed by Continuous qEEG Monitoring in a Rat Model of Ischemia-Reperfusion.Frontiers in neurology · 2021Article
- Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures.Scientific reports · 2020Article
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Authors and funding
13 authors.
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Abstract
Testosterone is responsible for several changes in the brain, including behavioral and emotional responses, memory, and cognition. Given this, we investigated changes in the brain wave profile caused by supplementation with exogenous testosterone in both castrated and non-castrated rats. We also investigated the serum testosterone levels, renal and hepatic function, and the lipid and behavioral profiles. We found changes in the spectral wave power in both groups (castrated and non-castrated animals) supplemented with exogenous testosterone, consistent with an aggressive/hostile profile. These changes were observed in the electrocorticographic evaluation associated with increased power in low-frequency (delta and theta) and high-frequency (beta and gamma) activity in the supplemented animals. The castrated animals presented a significant decrease of wave power in the alpha frequency. This correlated with a decrease of the performance of the animals in the elevated plus-maze evaluation, given that the alpha wave is linked to the execution and visualization of motor processes. In the behavioral evaluation, the castrated animals presented a reduced permanence time in the elevated-plus maze, although this was prevented by the supplementation of testosterone. Testosterone supplementation induced aggressive behavior in non-castrated animals, but not in castrated ones. Supplemented animals had significantly elevated serum testosterone levels, while their urea levels were significantly lower, but without clinical significance. Our data indicate that testosterone supplementation in non-castrated rats, but not in castrated ones, causes electrocorticographic changes that could be associated with more aggressive and hostile behavior, in addition to indicating a potential for personality disorder. However, further studies are required to elucidate the cellular and molecular changes caused by acute testosterone supplementation.
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