ReviewFrontiers in neurology2019
Small Vessel Disease.
Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- Pulsatility Assessment of Cerebral Perforating Arteries Using Submillimeter-Resolution Dual-VENC Phase-Contrast MRI at 3T.Journal of magnetic resonance imaging : JMRI · 2026Article
- Depression as an early symptom and risk factor of dementia - a narrative review.Frontiers in psychiatry · 2026Review
- Bariatric Surgery Impacts Retinal Vessel Status Assessed by Optical Coherence Tomography Angiography: A Prospective 12 Months Study.Journal of clinical medicine · 2025Article
- The Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage: Stratified Analysis by Age.Journal of clinical medicine · 2025Article
- Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Assessment of arterial pulsatility of cerebral perforating arteries using 7T high-resolution dual-VENC phase-contrast MRI.Magnetic resonance in medicine · 2024Article
- Cerebral Small Vessel Disease in Population-Based Research: What are We Looking at - and What not?Aging and disease · 2024Article
- Recurrent cerebrovascular events after recent small subcortical infarction.Journal of neurology · 2024Article
- Article
- Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.Nature communications · 2024Article
- Polyvascular atherosclerosis and renal dysfunction increase the odds of cognitive impairment in vascular disease: findings of the LipidCardio study.European journal of medical research · 2024Article
- Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study.GeroScience · 2024Article
- Exploring what progress is being made in the development of health promotion material for vascular dementia: A systematic review of the evidence.Aging medicine (Milton (N.S.W)) · 2023Review
- Methylenetetrahydrofolate reductase polymorphisms and elevated plasma homocysteine levels in small vessel disease.Brain and behavior · 2023Article
- Small-vessel disease in the brain.American heart journal plus : cardiology research and practice · 2023Article
- White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke-results from the PROSCIS-B study.Journal of neurology · 2023Article
- Small vessel disease: Connections between the kidney and the heart.American heart journal plus : cardiology research and practice · 2023Article
- A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease.Frontiers in aging neuroscience · 2023Article
- Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small vessel disease (SVD) refers to conditions where damage to arterioles and capillaries is predominant, leading to reduced, or interrupted perfusion of the affected organ. Data suggest that when this condition is evident in any organ, it is already systemic in its occurrence and consequences. SVD affects primarily organs that receive significant portions of cardiac output such as the brain, the kidney, and the retina. Thus, SVD is a major etiologic cause in debilitating conditions such as renal failure, blindness, lacunar infarcts, and dementia. The factors that lead to this devastating condition include all the known vascular risk factors when they are not strictly controlled, but lifestyles that include sedentary existence, obesity, and poor sleep patterns are also recognized drivers of SVD. In addition, depression is now recognized as a vascular risk factor. Inflammation is a mediator of SVD, but it is not known which factor(s) predominate in its etiology. This article emphasizes the need for more investigations to define this link further and suggests clinical and societal responses that might reduce the major impacts of this condition on populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.