Evidence map›Paper›PMID 31616310›Full record

ArticleFrontiers in physiology2019

Experimental Pulmonary Hypertension Is Associated With Neuroinflammation in the Spinal Cord.

Mylene Vaillancourt, Pamela Chia, Lejla Medzikovic, Nancy Cao, Gregoire Ruffenach, David Younessi, Soban Umar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mylene VaillancourtDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Pamela ChiaDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Lejla MedzikovicDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Nancy CaoDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Gregoire RuffenachDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
David YounessiDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Soban UmarDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

Role of the Novel MicroRNA-125b in Pulmonary Hypertension Associated with Pulmonary FibrosisK08HL141995 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI UMAR, SOBAN · 2019 to 2023
$879k
NHLBI NIH HHS K08 HL141995
6 · The paper itself

Abstract

rationalePulmonary hypertension (PH) is a rare but fatal disease characterized by elevated pulmonary pressures and vascular remodeling, leading to right ventricular failure and death. Recently, neuroinflammation has been suggested to be involved in the sympathetic activation in experimental PH. Whether PH is associated with neuroinflammation in the spinal cord has never been investigated. METHODS/

resultsPH was well-established in adult male Wistar rats 3-week after pulmonary endothelial toxin Monocrotaline (MCT) injection. Using the thoracic segments of the spinal cord, we found a 5-fold increase for the glial fibrillary acidic protein (GFAP) in PH rats compared to controls (

conclusionWe report for the first time evidence for neuroinflammation in the thoracic spinal cord of pulmonary hypertensive rats. The impact of spinal cord inflammation on cardiopulmonary function in PH remains elusive.

Indexed as

Monocrotalineneuroinflammationoxidative stresspulmonary hypertensionspinal cordsympathetic activationsympathetic nervous system

Identifiers

PMID31616310
PMCPMC6764190
OpenAlexW2971937855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.