Evidence map›Paper›PMID 31616290›Full record

ArticleFrontiers in pharmacology2019

The Trials and Tribulations of Structure Assisted Design of K

Heesung Shim, Brandon M Brown, Latika Singh, Vikrant Singh, James C Fettinger, Vladimir Yarov-Yarovoy, Heike Wulff

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Structural basis for the subtype-selective activation of KStructure (London, England : 1993) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. CaCurrent research in physiology · 2023
    Article
  10. Article
  11. Article
  12. Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 KProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. Subtype-selective positive modulation of KBritish journal of pharmacology · 2022
    Article
  15. Article
  16. Atomistic Insights of Calmodulin Gating of Complete Ion Channels.International journal of molecular sciences · 2020
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heesung ShimDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, CA, United States.
Brandon M BrownDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, CA, United States.
Latika SinghDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, CA, United States.
Vikrant SinghDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, CA, United States.
James C FettingerDepartment of Chemistry, University of California, Davis, Davis, CA, United States.
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA, United States.
Heike WulffDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, CA, United States.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Training and Education CoreU54NS079202 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEIN, PAMELA J · 2012 to 2021
$35.7M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Structure Assisted Design of SK Channel Selective ActivatorsR21NS101876 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WULFF, HEIKE · 2017 to 2018
$410k
NCATS NIH HHS UL1 TR001860NIGMS NIH HHS T32 GM099608NINDS NIH HHS R21 NS101876NINDS NIH HHS U54 NS079202
6 · The paper itself

Abstract

Calcium-activated K

Indexed as

calcium-activated potassium channelscalmodulin binding domainKCa2.2KCa3.1KCa activatorsRosettaSKA-111

Identifiers

PMID31616290
PMCPMC6764326

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.