ArticleFrontiers in aging neuroscience2019
Effects of Age and Sex on Subcortical Volumes.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- Greater temporo-occipital gray matter volume and frontoparietal cortical thickness in post-menopausal women: a UK Biobank study.Brain structure & function · 2026Article
- Thalamic Volume Asymmetry as a Potential Predictor of Vagus Nerve Stimulation Outcomes in Refractory Epilepsy.Neurologia medico-chirurgica · 2026Article
- Explicit and Implicit Emotion Processing: The Role of Spatial Frequencies in a Case Study of Right Capsulo-Thalamic Damage.Journal of Intelligence · 2026Article
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- In vivo growth trajectories of regional brain volumes in the Wistar rat.Neurobiology of aging · 2025Article
- Deep Learning and Atlas-Based MRI Segmentation Enable Longitudinal Characterization of Healthy Mouse Brain.Journal of imaging · 2025Article
- Sex-specific trajectories of hippocampal aging: structural changes and asymmetry across the lifespan.Neuroradiology · 2025Article
- Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults.Neurobiology of aging · 2025Article
- Age-Associated Cortical Thinning in Speech Motor Regions Precedes Hippocampal Decline: Implications for Alzheimer's Disease.Human brain mapping · 2025Article
- Longitudinal relationships between daily activity and hippocampal atrophy in Japanese dwellers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Associations Between Trail-Making Test Black and White Performance and Gray Matter Volume in Community-Dwelling Cognitively Healthy Adults Aged 40 to 80 Years.Journal of clinical medicine · 2025Article
- Age-Related Electroencephalographic Delta and Alpha Oscillations During Sedation with Target-Controlled Propofol Infusion.Journal of clinical medicine · 2025Article
- Revealing the Spatial Pattern of Brain Hemodynamic Sensitivity to Healthy Aging through Sparse Dynamic Causal Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Thalamus anatomy predicts cognitive performance and hippocampal atrophy in aging adults: a UK Biobank study.Brain communications · 2025Article
- Changes in Hippocampal Volume after Traumatic Brain Injury (TBI).Research square · 2024Article
- Anatomic Interpretability in Neuroimage Deep Learning: Saliency Approaches for Typical Aging and Traumatic Brain Injury.Neuroinformatics · 2024Article
- Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia.Scientific reports · 2024Article
- Lifespan development of thalamic nuclei and characterizing thalamic nuclei abnormalities in schizophrenia using normative modeling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex as a Determinant of Age-Related Changes in the Brain.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn an increasingly aging society, it is of great importance to consider trajectories of subcortical volumes at different ages for understanding biological markers of aging. Thus, we investigated sex, age, and their interactions on subcortical volumes, including the basal ganglia (caudate, putamen, accumbens, and pallidum), thalamus, hippocampus, and amygdala.
methodsWe analyzed the adult lifespan trajectory of subcortical volumes and asymmetries in 563 healthy subjects aged from 19 to 86 using magnetic resonance imaging (MRI) data from the publicly available 7IXI data set.
resultsThe sex made strong contributions to the trajectories of subcortical volumes with aging, including the right putamen, right pallidum, bilateral thalamus, hippocampus, and amygdala. The volume of the right putamen, right pallidum, and right thalamus decreased more rapidly in males than in females, and the volume of the left thalamus, bilateral hippocampus, and amygdala in males followed a quadratic model, while those in females followed a linear decline model. The asymmetries in the caudate and hippocampus showed a linear decline, and a sex and age interaction was found in the hippocampus; that is, the asymmetry in the hippocampus decreased only in the males and not in the females. Changes in the accumbens and pallidum fit quadratic trajectories, in which females increased until 39.26 years old in the accumbens asymmetry and then began to rapidly decline, and males showed a linear decline. The asymmetry in the pallidum in males and females showed a slow decreasing period until almost 45 years of age and then increased.
conclusionThe results suggest that compared with females, males have a faster decline in the volume of the right putamen, right pallidum, and right thalamus, while aging occurred later but also faster in the left thalamus, bilateral hippocampus, and amygdala. Interestingly, we found the inflection point in the thalamus, bilateral hippocampus, and amygdala volume in the quadratic model, and after this point, the volume change accelerated with aging, which may have resulted from the stronger work pressure in the middle-aged men and the low levels of testosterone in the older adults. The interaction of age and sex on individual subcortical structures provides evidence to support the impact of sex on psychopathologies associated with degenerative brain disorders in the elderly. The findings may be significant to investigate the occurrence and prevalence of degenerative brain disorders in males and females. Future studies can focus on the functional and behavioral relations with subcortical structures for preventive measures of related disorders.
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