Evidence map›Paper›PMID 31616223›Full record

ArticlePostepy dermatologii i alergologii2019

Ingenol mebutate treatment in actinic keratosis - clinical effectiveness and potential side effects.

Aleksandra Lesiak, Anna Maćkowska, Igor A Bednarski, Paweł Kolano, Irmina Olejniczak-Staruch, Anna Woźniacka, Joanna Sieniawska, Joanna Narbutt

Open access · goldAbstract read
In one paragraph

Article in Postepy dermatologii i alergologii, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Diterpenoids from the Aerial Parts ofMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aleksandra LesiakDepartment of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Lodz, Poland.
Anna MaćkowskaStudent Research Group at Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Lodz, Poland.
Igor A BednarskiDepartment of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Lodz, Poland.
Paweł KolanoDepartment of General and Oncological Surgery, Tomaszow Health Centre, Tomaszow Mazowiecki, Poland.
Irmina Olejniczak-StaruchDepartment of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
Anna WoźniackaDepartment of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
Joanna SieniawskaDepartment of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
Joanna NarbuttDepartment of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Lodz, Poland.
Medical University of Lodz · PLRzeszów University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionActinic keratosis is a common skin disease that occurs in response to prolonged exposure to ultraviolet radiation. This problem affects up to 60% of the population over 40 years of age. Actinic keratosis is considered to be a precancerous lesion leading to squamous cell carcinoma (SCC). The new therapeutic option for the treatment of actinic keratosis is ingenol mebutate gel (0.015%, 0.05%).

aimRetrospective evaluation of response and potential side effects of ingenol mebutate treatment in clinical practice. MATERIAL AND

methodsEight patients with actinic keratosis lesions on the face or scalp self-applied a 0.015% gel for 3 consecutive days on the 25 cm

resultsAll patients on day 57 presented a complete absence of AK lesions in the area of ingenol mebutate application. No adverse events were observed.

conclusionsOur study shows that ingenol mebutate is highly efficacious field treatment for actinic keratosis.

Indexed as

actinic keratosisingenol mebutate

Identifiers

PMID31616223
PMCPMC6791158
OpenAlexW2979908021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.