Evidence map›Paper›PMID 31616164›Full record

ArticleOncoTargets and therapy2019

Protective effect of

Jorge Luis Arroyo-Acevedo, Juan Pedro Rojas-Armas, Oscar Herrera-Calderón, Roberto Chávez-Asmat, Hugo Jesús Justil-Guerrero, Cristian Aguilar-Carranza, Edwin Enciso-Roca, Johnny Aldo Tinco-Jayo, Ricardo Ángel Yuli-Posadas, Cesar Franco-Quino and 1 more

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Jorge Luis Arroyo-AcevedoLaboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor De San Marcos, Lima, Peru.
Juan Pedro Rojas-ArmasLaboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor De San Marcos, Lima, Peru.
Oscar Herrera-CalderónLaboratory of Pharmacognosy and Traditional Medicine, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor De San Marcos, Lima, Peru.
Roberto Chávez-AsmatAssociation for the Development of Student Research in Health Sciences (ADIECS), Lima, Peru.
Hugo Jesús Justil-GuerreroLaboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor De San Marcos, Lima, Peru.
Cristian Aguilar-CarranzaDepartment of Pathology, National Cardiovascular Institute, Lima, Peru.
Edwin Enciso-RocaFaculty of Health Sciences, Universidad Nacional De San Cristóbal De Huamanga, Ayacucho, Peru.
Johnny Aldo Tinco-JayoFaculty of Health Sciences, Universidad Nacional De San Cristóbal De Huamanga, Ayacucho, Peru.
Ricardo Ángel Yuli-PosadasUniversidad Continental, Huancayo, Peru.
Cesar Franco-QuinoFaculty of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Victor Chumpitaz-CerrateLaboratory of Pharmacology, Universidad Científica Del Sur, Lima, Peru.
National University of San Marcos · PESan Cristóbal of Huamanga University · PEGroup for the Analysis of Development · PEUniversidad Científica del Sur · PEUniversidad Continental · PEUniversidad Peruana Cayetano Heredia · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objective

methodsFifty-six albino male rats were randomized into seven groups: I) negative control: physiological serum: 2 mL/kg; II) TCN: testosterone 100 mg/kg + cyproterone 50 mg/kg + NMU 50 mg/kg; III) TCN + S40 (simvastatin 40 mg/kg); IV) TCN + ChS250 (ChS 250 mg/kg); V) TCN + ChS50 (ChS 50 mg/kg) + S40; VI) TCN + ChS250 (ChS 250 mg/kg) + S40; and VII) TCN + ChS500 (ChS 500 mg/kg) + S40. The antioxidant activity was tested by using (2,2-diphenyl-1-picrylhydrazyl) (DPPH) assay. Hematology, toxicological biochemical parameters, prostate-specific antigen (PSA), histology and prostate size were evaluated as main indicators of protective effect.

resultsTriglyceride values were decreased in the groups receiving ChS, being significant (

conclusionIn experimental conditions, the ethanolic extract of

Indexed as

anti-tumorChuquiraga spinosaprostate cancersimvastatin

Identifiers

PMID31616164
PMCPMC6699590
OpenAlexW2967109787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.