Evidence map›Paper›PMID 31615936›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2020

Genomic Profiling Identifies Association of

Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D Tap, Nicola Fabbri and 6 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Clinical Efficacy of Olaparib inJCO precision oncology · 2021
    Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Evaluation of the Idylla IDH1-2 Mutation Assay for the Detection ofInternational journal of molecular sciences · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Long-term Safety and Clinical Activity in Patients with Conventional Chondrosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Guo Gord ZhuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Khedoudja NafaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Narasimhan AgaramDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ahmet ZehirDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-5406-4104
Ryma BenayedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-3754-0321
Justyna SadowskaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-5342-2723
Laetitia BorsuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ciara KellyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
William D TapDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-7779-2796
Nicola FabbriOrthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Edward AthanasianOrthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Patrick J BolandOrthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
John H HealeyOrthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael F BergerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Marc LadanyiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Meera HameedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. hameedm@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeChondrosarcomas are the second most common primary malignant bone tumors. Although histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability. Isocitrate dehydrogenase 1 ( EXPERIMENTAL

designWe performed hotspot sequencing of

resultsAlthough no association was discovered between

conclusions

Indexed as

MutationAdolescentAdultAgedBiomarkers, TumorBone NeoplasmsChondrosarcomaCyclin-Dependent Kinase Inhibitor p16FemaleGenomicsHigh-Throughput Nucleotide SequencingHumansIsocitrate DehydrogenaseMaleMiddle AgedNeoplasm GradingBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16IDH1 protein, humanIDH2 protein, humanIsocitrate DehydrogenaseTelomeraseTERT protein, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID31615936
PMCPMC6980683
OpenAlexW2980490927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.