Evidence map›Paper›PMID 31615901›Full record

ArticleScience signaling2019

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.

Miho Watanabe, Jinwei Zhang, M Shahid Mansuri, Jingjing Duan, Jason K Karimy, Eric Delpire, Seth L Alper, Richard P Lifton, Atsuo Fukuda, Kristopher T Kahle

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
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  6. Neuronal KActa pharmacologica Sinica · 2024
    Review
  7. Article
  8. The role ofJournal of pharmaceutical analysis · 2023
    Review
  9. KFrontiers in cellular neuroscience · 2023
    Article
  10. Maternal taurine as a modulator of ClFrontiers in cellular neuroscience · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
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  17. Review
  18. Review
  19. Chloride Homeostasis in Developing Motoneurons.Advances in neurobiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Miho WatanabeDepartment of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.ORCID 0000-0003-3342-2210
Jinwei ZhangInstitute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.ORCID 0000-0001-8683-509X
M Shahid MansuriDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-1854-931X
Jingjing DuanHuman Aging Research Institute, School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.ORCID 0000-0003-2716-2627
Jason K KarimyDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0002-3702-1599
Seth L AlperDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-6228-2512
Richard P LiftonLaboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.
Atsuo FukudaDepartment of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. kristopher.kahle@yale.edu axfukuda@hama-med.ac.jp.ORCID 0000-0001-7112-4834
Kristopher T KahleDepartments of Neurosurgery, Pediatrics, and Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA. kristopher.kahle@yale.edu axfukuda@hama-med.ac.jp.ORCID 0000-0002-5922-7547
Yale University · USHamamatsu University School of Medicine · JPBroad Institute · USNanchang University · CNUniversity of Exeter · GBVanderbilt University · US

Funding

Transitioning Early Career Neurosurgeons to Scientific IndependenceK12NS080223 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2012 to 2022
$9.2M
Human Genetics and Molecular Mechanisms of Congenital HydrocephalusR01NS111029 · NINDS · YALE UNIVERSITY · PI DENIZ, ENGIN, JIN, SHENG CHIH · 2020 to 2024
$2.5M
Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in HydrocephalusR01NS109358 · NINDS · YALE UNIVERSITY · PI Kristopher T. Kahle · 2018 to 2026
$2.4M
NINDS NIH HHS K12 NS080223NINDS NIH HHS R01 NS109358NINDS NIH HHS R01 NS111029
6 · The paper itself

Abstract

Despite its importance for γ-aminobutyric acid (GABA) inhibition and involvement in neurodevelopmental disease, the regulatory mechanisms of the K

Indexed as

AnimalsAnimals, NewbornBinding SitesCells, CulturedCentral Nervous SystemChloridesgamma-Aminobutyric AcidGene Expression Regulation, DevelopmentalK Cl- CotransportersMaleMice, 129 StrainMice, Inbred C57BLMice, KnockoutNeuronsPhosphorylationSignal TransductionChloridesgamma-Aminobutyric AcidK Cl- CotransportersSymporters

Identifiers

PMID31615901
PMCPMC7219477
OpenAlexW2980322270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.