ReviewCold Spring Harbor perspectives in medicine2020
Clinical Perspectives in Brain Metastasis.
Review in Cold Spring Harbor perspectives in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Coplanar versus non-coplanar volumetric modulated arc therapy for hippocampal avoidance whole brain radiotherapy using Monte Carlo-based planning system.Radiological physics and technology · 2026Article
- Artificial Intelligence-Based MRI Segmentation in Glioblastoma and Single Brain Metastasis: An Exploratory Study of Diagnostic and Prognostic Value.Life (Basel, Switzerland) · 2026Article
- Brain imaging screening in metastatic breast cancer: patients' and physicians' perspectives.Breast (Edinburgh, Scotland) · 2025Article
- Article
- From pre-clinical to translational brain metastasis research: current challenges and emerging opportunities.Clinical & experimental metastasis · 2024Review
- Spine Metastasis Is Associated with the Development of Brain Metastasis in Non-Small-Cell Lung Cancer Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Immunotherapy revolutionizing brain metastatic cancer treatment: personalized strategies for transformative outcomes.Frontiers in immunology · 2024Review
- Advances in determining the gross tumor target volume for radiotherapy of brain metastases.Frontiers in oncology · 2024Review
- HER2-Directed Therapy in Advanced Breast Cancer: Benefits and Risks.OncoTargets and therapy · 2023Review
- Comparison of immunotherapy combined with stereotactic radiotherapy and targeted therapy for patients with brain metastases: A systemic review and meta-analysis.Open life sciences · 2023Article
- Pyrotinib combining with radiotherapy on breast cancer with brain metastasis.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Prognostic factors among patients with brain metastases from cancer of unknown primary site.Journal of neuro-oncology · 2022Article
- Cortisol promotes breast-to-brain metastasis through the blood-cerebrospinal fluid barrier.Cancer reports (Hoboken, N.J.) · 2022Article
- Use of predictive spatial modeling to reveal that primary cancers have distinct central nervous system topography patterns of brain metastasis.Journal of neurosurgery · 2022Article
- The microenvironment of brain metastases from solid tumors.Neuro-oncology advances · 2021Article
- Brain Metastases in HER2-Positive Breast Cancer: Current and Novel Treatment Strategies.Cancers · 2021Review
- Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory.Current protocols · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metastases (BMs) are responsible for decline in neurological function, reduction in overall quality of life, and mortality from recurrent or untreatable lesions. Advances in diagnostics and imaging have led to increased detection of central nervous system (CNS) metastases in patients with progressive cancers. Improved control of extracranial systemic disease, and the limited ability of current therapeutics to cross the blood-brain barrier (BBB) also contribute to the increase in incidence of brain metastases, as tumor cells seek refuge in the brain. Surgery, chemotherapy, and/or radiation (whole-brain radiation therapy and stereotactic radiation surgery [WBRT/SRS]) are a clinically established treatment paradigm for patients with brain metastases. With the advent of genetic and molecular characterization of tumors and their immune microenvironment, clinical trials seek to include targeted drugs into the therapeutic regimen for eligible patients. Several challenges, like treatment of multiple CNS lesions, superior uptake of chemotherapy into the brain, and trials with multidisciplinary approaches, are now being clinically addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.