Evidence map›Paper›PMID 31615841›Full record

ArticleThe Journal of biological chemistry2019

Cytoplasmic dsRNA induces the expression of

Guanming Wang, Takahisa Kouwaki, Kazuki Mugikura, Masaaki Okamoto, Hiromi Takaki, Kenji Funami, Tsukasa Seya, Hiroyuki Oshiumi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Guanming WangDepartment of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 Japan.
Takahisa KouwakiDepartment of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 Japan.
Kazuki MugikuraNebuta Research Institute for Life Sciences, Aomori University, Kohbata 2-3-1, Aomori 030-0943, Japan.
Masaaki OkamotoDepartment of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 Japan.
Hiromi TakakiNebuta Research Institute for Life Sciences, Aomori University, Kohbata 2-3-1, Aomori 030-0943, Japan.
Kenji FunamiNebuta Research Institute for Life Sciences, Aomori University, Kohbata 2-3-1, Aomori 030-0943, Japan.
Tsukasa SeyaNebuta Research Institute for Life Sciences, Aomori University, Kohbata 2-3-1, Aomori 030-0943, Japan seya-tu@pop.med.hokudai.ac.jp.
Hiroyuki OshiumiDepartment of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 Japan oshiumi@kumamoto-u.ac.jp.ORCID 0000-0003-1567-8722
Aomori University · JPKumamoto University · JPHokkaido University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoplasmic dsRNA is recognized by RNA helicase RIG-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), triggering induction of the innate immune response via the mitochondrial antiviral signaling protein (MAVS). In contrast, extracellular dsRNA is internalized into endosomes and recognized by Toll-like receptor 3 (TLR3), which triggers signaling via the Toll-like receptor adaptor molecule 1 (TICAM-1). Poly(I:C) is a synthetic dsRNA analog and increases the expression of

Indexed as

Cell DifferentiationCell LineCytoplasmHumansKruppel-Like Factor 4Nanog Homeobox ProteinOctamer Transcription Factor-3Organic Cation Transporter 3Organic Cation Transport ProteinsProto-Oncogene MasRNA, Double-StrandedRNA, MessengerKLF4 protein, humanKruppel-Like Factor 4MAS1 protein, humanNanog Homeobox ProteinNANOG protein, humanOctamer Transcription Factor-3Organic Cation Transporter 3Organic Cation Transport ProteinsPOU5F1 protein, humanProto-Oncogene MasRNA, Double-StrandedRNA, Messengerinduced pluripotent stem cell (iPS cell) (iPSC)innate immunityinterferon regulatory factor (IRF)RIG-I-like receptor (RLR)signal transductionvirus

Identifiers

PMID31615841
PMCPMC6916484
OpenAlexW2981031151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.