ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Threat Memory Reminder Under Matrix Metalloproteinase 9 Inhibitor Doxycycline Globally Reduces Subsequent Memory Plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.European journal of psychotraumatology · 2026Trial
- The impact of doxycycline on human contextual fear memory.Psychopharmacology · 2024Trial
- Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory.eNeuro · 2023Trial
- Information sharing within a social network is key to behavioral flexibility-Lessons from mice tested under seminaturalistic conditions.Science advances · 2025Article
- Article
- Measuring human context fear conditioning and retention after consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Enriched environmental exposure reduces the onset of action of the serotonin norepinephrin reuptake inhibitor venlafaxine through its effect on parvalbumin interneurons plasticity in mice.Translational psychiatry · 2023Article
- Measuring human trace fear conditioning.Psychophysiology · 2022Article
- Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning.Science advances · 2021Article
- Saccadic scanpath length: an index for human threat conditioning.Behavior research methods · 2021Article
- Extracellular matrix remodeling with stress and depression: Studies in human, rodent and zebrafish models.The European journal of neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Associative memory can be rendered malleable by a reminder. Blocking the ensuing reconsolidation process is suggested as a therapeutic target for unwanted aversive memories. Matrix metalloproteinase-9 (MMP-9) is required for structural synapse remodeling involved in memory consolidation. Inhibiting MMP-9 with doxycycline is suggested to attenuate human threat conditioning. Here, we investigated whether MMP-9 inhibition also interferes with threat memory reconsolidation. Male and female human participants (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.