ReviewCold Spring Harbor perspectives in biology2020
Specification of the First Mammalian Cell Lineages In Vivo and In Vitro.
Review in Cold Spring Harbor perspectives in biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Wnt/β-catenin signalling modulates the timing of cell fate decision making in the early mouse embryo.PloS one · 2026Article
- Role of CEBPa in trophectoderm competence installment.Science advances · 2025Article
- Exploring and validating the marmoset as a primate model for chromosomal instability in early development.Molecular human reproduction · 2025Article
- Revisiting trophectoderm-inner cell mass lineage segregation in the mammalian preimplantation embryo.Human reproduction (Oxford, England) · 2024Review
- Roles and Regulation of H3K4 Methylation During Mammalian Early Embryogenesis and Embryonic Stem Cell Differentiation.Advances in experimental medicine and biology · 2024Review
- The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization.Nature communications · 2023Article
- Blastomeres of 8-cell mouse embryos differ in their ability to generate embryonic stem cells and produce lines with different transcriptional signatures.Frontiers in cell and developmental biology · 2023Article
- Editorial: Molecular and cellular mechanisms in preimplantation IVF-embryo development.Frontiers in cell and developmental biology · 2023Article
- Epigenetic reorganization during early embryonic lineage specification.Genes & genomics · 2022Review
- Chromatin remodeler INO80 mediates trophectoderm permeability barrier to modulate morula-to-blastocyst transition.Zoological research · 2021Article
- Cytoskeletal control of early mammalian development.Nature reviews. Molecular cell biology · 2021Review
- Review
- METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development‡.Biology of reproduction · 2021Article
- Histone Arginine Methyltransferase CARM1-Mediated H3R26me2 Is Essential for Morula-to-Blastocyst Transition in Pigs.Frontiers in cell and developmental biology · 2021Article
- Integrating cellular dimensions with cell differentiation during early development.Current opinion in cell biology · 2020Review
- Epigenetic regulation of mouse preimplantation embryo development.Current opinion in genetics & development · 2020Review
- Development of Pre-implantation Mammalian Blastocyst.Advances in anatomy, embryology, and cell biologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Our understanding of how the first mammalian cell lineages arise has been shaped largely by studies of the preimplantation mouse embryo. Painstaking work over many decades has begun to reveal how a single totipotent cell is transformed into a multilayered structure representing the foundations of the body plan. Here, we review how the first lineage decision is initiated by epigenetic regulation but consolidated by the integration of morphological features and transcription factor activity. The establishment of pluripotent and multipotent stem cell lines has enabled deeper analysis of molecular and epigenetic regulation of cell fate decisions. The capability to assemble these stem cells into artificial embryos is an exciting new avenue of research that offers a long-awaited window into cell fate specification in the human embryo. Together, these approaches are poised to profoundly increase our understanding of how the first lineage decisions are made during mammalian embryonic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.