ArticlePsychological medicine2020
Inflammation and depressive phenotypes: evidence from medical records from over 12 000 patients and brain morphology.
Article in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
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- Comorbid mechanisms of psoriasis and mental disorders: an analysis of inflammatory and psychosocial interactions.Frontiers in psychiatry · 2026Review
- Polygenic score for C-reactive protein is linked to faster cortical thinning and psychopathology risk in adolescents.Nature. Mental health · 2026Article
- Natural language processing to identify suicidal ideation and anhedonia in major depressive disorder.BMC medical informatics and decision making · 2025Article
- Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.Alzheimer's research & therapy · 2023Article
- The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites.Genome biology · 2022Article
- Association between depression scores and comprehensive geriatric assessment and frailty in geriatric outpatients with somatic complaints: an observational cross-sectional study.Turkish journal of medical sciences · 2022Observational
- Effects of stress on endophenotypes of suicide across species: A role for ketamine in risk mitigation.Neurobiology of stress · 2022Review
- Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders.The European journal of neuroscience · 2022Review
- C-Reactive Protein: Marker of risk for post-traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery.The European journal of neuroscience · 2022Review
- Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression.Life (Basel, Switzerland) · 2021Article
- Post-acute sequelae of COVID-19: Evidence of mood & cognitive impairment.Brain, behavior, & immunity - health · 2021Article
- Does inflammation link stress to poor COVID-19 outcome?Stress and health : journal of the International Society for the Investigation of Stress · 2021Review
- Molecular and Neural Mechanism of Dysphagia Due to Cancer.International journal of molecular sciences · 2021Review
- Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder.Brain, behavior, and immunity · 2021Article
- Personalized Medicine Using Neuroimmunological Biomarkers in Depressive Disorders.Journal of personalized medicine · 2021Review
- Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat.Journal of neuroinflammation · 2020Article
- Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.Cell proliferation · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPreclinical and human studies suggest an association between chronic inflammation and the development of depressive behaviors. This is proposed to occur through downstream effects of inflammatory cytokines on neuroplasticity, neurogenesis and neurotransmitter function, although the neural correlates remain poorly understood in humans.
methodsIn Study 1, structural magnetic resonance imaging and serum inflammatory cytokine data were analyzed from 53 psychiatrically healthy female participants. Correlational analyses were conducted between interleukin-6 (IL-6) and volume in a priori regions implicated in the pathophysiology of major depressive disorder (MDD). In Study 2, medical data [including serum inflammatory acute phase reactants (C-reactive protein)] were analyzed for 12 589 participants. Participants were classified as having (n = 2541) v. not having (n = 10 048) probable lifetime MDD using phenotypes derived using machine-learning approaches. Non-parametric analyses compared inflammation between groups, whereas regression analyses probed whether inflammation predicted probable MDD classification while accounting for other variables.
resultsIn Study 1, significant negative correlations emerged between IL-6 and hippocampal, caudate, putamen and amygdalar volume. In Study 2, the MDD group showed a higher probability of elevated inflammation than the non-MDD group. Moreover, elevated inflammation was a significant predictor of probable MDD classification.
conclusionsFindings indicate that inflammation is cross-sectionally related to reduced volume in brain regions implicated in MDD phenotypes among a sample of psychiatrically healthy women, and is associated with the presence of probable MDD in a large clinical dataset. Future investigations may identify specific inflammatory markers predicting first MDD onset.
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