ArticleBMC surgery2019
Feasibility of subtotal esophagectomy with systematic lymphadenectomy in selected elderly patients with esophageal cancer; a propensity score matching analysis.
Article in BMC surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Epidemiology of cancer in older adults: a systematic review of age-related differences in solid malignancies treatment.Current oncology reports · 2025Pooled it
- Optimal treatment strategy for older patients with esophageal squamous cell carcinoma: A multicenter retrospective study.Oncology letters · 2025Article
- Survival outcome of esophagectomy and chemoradiotherapy for resectable esophageal squamous cell carcinoma in patients >75 years of age.Thoracic cancer · 2024Article
- Prognostic Factors and Outcomes in Elderly Esophagectomy Patients with Esophageal Cancer.Annals of surgical oncology · 2024Article
- Management of esogastric cancer in older patients.Therapeutic advances in medical oncology · 2024Review
- Frailty Assessed by the Clinical Frailty Scale is Associated with Prognosis After Esophagectomy.Annals of surgical oncology · 2023Article
- Outcomes of elderly patients following thoracoscopic esophagectomy for esophageal cancer.Langenbeck's archives of surgery · 2023Article
- Safety and short-term efficacy of preoperative FOLFOX therapy in patients with resectable esophageal squamous cell carcinoma who are ineligible for cisplatin.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Management of elderly patients with esophageal squamous cell cancer.Japanese journal of clinical oncology · 2022Review
- Impact of frailty on the long-term outcomes of elderly patients with esophageal squamous cell carcinoma.General thoracic and cardiovascular surgery · 2022Article
- Long-term Outcomes Following Esophagectomy in Older and Younger Adults with Esophageal Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Outcomes of trimodality CROSS regimen in older adults with locally advanced esophageal cancer.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2021Article
- Esophageal Cancer in Elderly Patients, Current Treatment Options and Outcomes; A Systematic Review and Pooled Analysis.Cancers · 2021Review
- Outcomes of curative esophageal cancer surgery in elderly: A meta-analysis.World journal of gastrointestinal oncology · 2021Article
- Treatment Outcomes and the Safety of Chemoradiotherapy With High-Dose CDDP for Elderly Patients With Head and Neck Squamous Cell Carcinoma: A Propensity Score Matching Study.Frontiers in surgery · 2021Article
- Newly developed primary malignancies in long-term survivors who underwent curative esophagectomy for squamous cell carcinoma of the esophagus.Surgery today · 2021Article
- Strategies to prevent anastomotic leakage after esophagectomy and gastric conduit reconstruction.Langenbeck's archives of surgery · 2020Review
- Surveillance of Esophageal Cancer in the Republic of Uzbekistan from 2000 to 2018.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Outcomes of Older Patients Undergoing Surgery for Esophageal Squamous Cell Carcinoma.In vivo (Athens, Greece)Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe global increase in elderly populations is accompanied by an increasing number of candidates for esophagectomy. Here we aimed to determine the postoperative outcomes after subtotal esophagectomy in elderly patients with esophageal cancer.
methodsPatients (n = 432) with who underwent curative-intent transthoracic subtotal esophagectomy with 2- or 3-field lymphadenectomies for thoracic esophageal cancer were classified as follows: non-elderly (age < 75 years, n = 373) and elderly (age ≥ 75 years, n = 59) and groups. To balance the essential variables including neoadjuvant treatment and stage of progression, we conducted propensity score analysis, and clinical characteristics, perioperative course and prognosis were compared.
resultsAfter two-to-one propensity score matching, 100 and 50 patients were classified in the non-elderly and elderly groups. The elderly group had more comorbidities and lower preoperative cholinesterase activities and prognostic nutrition indexes. Although incidences of postoperative pneumonia, arrhythmia and delirium were slightly increased in the elderly group, no significant differences were observed in overall incidence of postoperative complications, rates of repeat surgery and death caused by surgery, and length of postoperative hospital stay between the two groups. There were no significant differences in disease-free and disease-specific survival as well as overall survival between the two groups.
conclusionOlder age (≥75 years) had limited impact on morbidity, disease recurrence, and survival after subtotal esophagectomy. Therefore, age should not prevent older patients from benefitting from surgery.
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