ArticleBMC infectious diseases2019
Microorganisms involved in deep neck infection (DNIs) in Greece: detection, identification and susceptibility to antimicrobials.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Temporal Trends in Pathogens and Clinical Outcomes of Adult Deep Neck Infections: An 18-Year Multicenter Cohort Study of 12,063 Cases.Microorganisms · 2026Article
- Bacterial etiology, antimicrobial susceptibility, and clinical outcomes in cervicofacial space infections before, during, and after the COVID-19 pandemic: a 10-year single-centre study.BMC infectious diseases · 2026Article
- Factors associated with complications among deep neck infections in a community-based hospital in Thailand.BMC infectious diseases · 2026Article
- Delayed Recognition and Drainage of a Pediatric Retropharyngeal Abscess with Parapharyngeal Extension in a Resource-Limited Setting: A Case Report.International medical case reports journal · 2026Article
- Antibiotic-Only Treatment of Pediatric Retropharyngeal and Parapharyngeal Abscess: A Case Report.Cureus · 2025Article
- Swabs versus native specimens in severe head and neck infections: a prospective pilot study and suggestions for clinical management.Oral and maxillofacial surgery · 2025Article
- Application of metagenomic next-generation sequencing in treatment guidance for deep neck space abscess.BMC microbiology · 2025Article
- Pharyngeal Mucosal Space Abscess: A Special Entity That Merits Special Management-Our Experience in 106 Cases.Journal of clinical medicine · 2025Article
- Management of Deep Neck Infection Associated with Descending Necrotizing Mediastinitis: A Scoping Review.Medicina (Kaunas, Lithuania) · 2025Article
- Deep Neck Infections: The Effectiveness of Therapeutic Management and Bacteriological Profile.Medicina (Kaunas, Lithuania) · 2025Observational
- Suppurative Cervicomediastinitis From the Perspective of the Head and Neck Surgeon in a Tertiary Treatment Unit.Cureus · 2024Article
- Intra-oral Drainage of Submandibular Abscess: A Minimally Invasive Technique. A Prospective Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Parapharyngeal and floor-of-mouth abscess secondary to tonsillar phlegmon: A rare and unusual cause of Ludwig's angina.Clinical case reports · 2022Article
- Should preoperative computed tomography be routine examination for cervicofacial space infections?BMC infectious diseases · 2022Article
- Bacteriological analysis based on disease severity and clinical characteristics in patients with deep neck space abscess.BMC infectious diseases · 2022Article
- The Efficacy of Pyogenic Cavity Aerobic Therapy with Negative Pressure Drainage in the Treatment of Deep Neck Space Infections.Infection and drug resistance · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine, from October 2010 to October 2018, the epidemiology of Deep Neck Infections (DNIs), regarding the detection, the identification and the susceptibility to antimicrobials of causative microorganisms, in Thessaly-Central Greece.
methodsAn analysis of data from a prospective database was conducted on 610 consecutive patients with DNIs treated in the Otolaryngology / Head & Neck Surgery Department of University Hospital of Larissa. Demographics, clinical features and microbiological data were analyzed.
resultsAmong the 610 patients (1,9/1 male to female ratio, mean age: 39,24 ± 17,25) with DNIs, 579 had a single space (94,9%), while the remaining 31 had a multi-space (5,1%) DNI. The most common areas affected were the peritonsillar space (84,6%) followed by the submandibular space (6,5%). Clinical samples were obtained from 462 patients, and were tested by culture and by the application of 16S rRNA PCR. Two hundred fifty-five samples (55,2%) gave positive cultures, in which Streptococcus pyogenes and Staphylococcus aureus were predominant. The application of the 16S rRNA PCR revealed that 183 samples (39,6%) were positive for bacterial DNA; 22 of them, culture negative, were found to be positive for anaerobic (Fusobacterium necrophorum, Actinomyces israellii etc) and for fastidious microorganisms (Brucella mellitensis, Mycobacterium avium).
conclusionDNIs represent a medical and surgical emergency and evidence-guided empirical treatment with intravenous infusion of antibiotics at the time of diagnosis is mandatory, highlighting the importance of epidemiological studies regarding the causative microorganisms. Although, in our study, the predominant pathogens were S. pyogenes and S. aureus, the combination of culture and molecular assay revealed that anaerobic bacteria play also a significant role in the pathogenesis of DNIs. Based on the local epidemiology, we propose as empirical therapy the intravenous use of a beta-lactam /beta-lactamase inhibitor; metronidazole or clindamycin can be added only in specific cases such as in immunocompromised patients.
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