Trial reportBMC neurology2019
Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study.
Trial report in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Prospective open-label trial of personalised connectivity-guided transcranial magnetic stimulation therapy for migraine.The journal of headache and pain · 2026Trial
- Citalopram Neuroendocrine Challenge Shows Altered Tryptophan and Kynurenine Metabolism in Migraine.Cells · 2022Trial
- The cortical morphology of cingulate cortex and microarchitecture of cingulum bundle correlate with cancer pain and anxiety in lung cancer patients.Brain imaging and behavior · 2026Article
- Posterior insular cortex hyperactivation drives vestibular migraine and comorbid anxiety.The journal of headache and pain · 2026Article
- Increasing the Construct Validity of Computational Phenotypes of Mental Illness Through Active Inference and Brain Imaging.Brain sciences · 2024Review
- Aberrant functional connectivity in anterior cingulate gyrus subregions in migraine without aura patients.Frontiers in neurology · 2024Article
- Two distinct neuroanatomical subtypes of migraine without aura revealed by heterogeneity through discriminative analysis.Brain imaging and behavior · 2023Article
- Longitudinal differences in iron deposition in periaqueductal gray matter and anterior cingulate cortex are associated with response to erenumab in migraine.Cephalalgia : an international journal of headache · 2023Article
- Neocortical circuits in pain and pain relief.Nature reviews. Neuroscience · 2021Review
- Suppression of neuropathic pain and comorbidities by recurrent cycles of repetitive transcranial direct current motor cortex stimulation in mice.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered serotonergic neurotransmission has been repeatedly implicated in the pathophysiology of migraine, although the exact mechanism is not known. Thus, our aim was to investigate the relationship between acute increase of brain serotonin (5-HT) level and the activation changes of the ACC using pharmacological challenge MRI (phMRI) in migraine patients and healthy controls.
methodsTwenty-seven pain-free healthy controls and six migraine without aura patients participated in the study. All participant attended to two phMRI sessions during which intravenous citalopram, a selective serotonin reuptake inhibitor (SSRI), or placebo (normal saline) was administered. We used region of interest analysis of ACC to compere the citalopram evoked activation changes of this area between patients and healthy participants.
resultsSignificant difference in ACC activation was found between control and patient groups in the right pregenual ACC (pgACC) during and after citalopram infusion compared to placebo. The extracted time-series showed that pgACC activation increased in migraine patients compared to controls, especially in the first 8-10 min of citalopram infusion.
conclusionsOur results demonstrate that a small increase in 5-HT levels can lead to increased phMRI signal in the pregenual part of the ACC that is involved in processing emotional aspects of pain. This increased sensitivity of the pgACC to increased 5-HT in migraine may contribute to recurring headache attacks and increased stress-sensitivity in migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.