Evidence map›Paper›PMID 31615323›Full record

ArticleMolecular pain

Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain.

Solomiya Tsymbalyuk, Madeleine Smith, Charles Gore, Orest Tsymbalyuk, Svetlana Ivanova, Charles Sansur, Volodymyr Gerzanich, J Marc Simard

Abstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Brivaracitam Ameliorates Increased Inflammation, Oxidative Stress, and Acetylcholinesterase Activity in Ischemic Mice.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
  3. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Potential novel therapeutic strategies for neuropathic pain.Frontiers in molecular neuroscience · 2023
    Review
  8. Brivaracetam exhibits mild pro-inflammatory features in anFrontiers in cellular neuroscience · 2022
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Solomiya TsymbalyukDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Madeleine SmithDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Charles GoreDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Orest TsymbalyukDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Svetlana IvanovaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Charles SansurDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Volodymyr GerzanichDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
J Marc SimardDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5373-1988

Funding

Fn14, non-canonical NF-kappaB and downstream signaling in neuropathic painR01NS105633 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2018 to 2022
$1.9M
NINDS NIH HHS R01 NS105633RRD VA I01 RX003060
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsDisease Models, AnimalHyperalgesiaImmunohistochemistryMaleMiceMice, Inbred C57BLNeuralgiaPyrrolidinonesbrivaracetamPyrrolidinonesastrocyteBrivaracetamlevetiracetammicrogliamouseneuropathic painsciatic nerve cuff modelT lymphocyte

Identifiers

PMID31615323
PMCPMC6880061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.