ArticleJournal of the American Heart Association2019
Blood Pressure and Heart Rate Variability in Preschool Children Exposed to Smokeless Tobacco in Fetal Life.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Effect of maternal smoking during pregnancy on child blood pressure in a European cohort.Scientific reports · 2022Trial
- Snus, nicotine pouches and cardiovascular disease: Evidence, mechanisms, and the challenge of novel nicotine products.Journal of internal medicine · 2026Review
- The Impact of Maternal/In Utero Exposure of Novel Tobacco Products on the Offspring Cardiovascular Health.Cardiovascular toxicology · 2025Review
- Association of secondhand smoke exposure during pregnancy with left ventricle structure and function in offspring at 4 years old: a prospective birth cohort study.BMC pregnancy and childbirth · 2025Article
- Fetal development and the air pollution exposome: an integrative perspective of health pathways.Frontiers in cellular neuroscience · 2025Article
- Arterial Stiffness and Carotid Intima-Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life.Journal of the American Heart Association · 2024Article
- Foetal tobacco and cannabis exposure, body fat and cardio-metabolic health in childhood.Pediatric obesity · 2022Article
- Toxic effects of smokeless tobacco on female reproductive health: A review.Current research in toxicology · 2022Review
- Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications.Frontiers in physiology · 2022Review
- Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?Frontiers in cardiovascular medicine · 2021Review
- Early Life Exposure to Nicotine: Postnatal Metabolic, Neurobehavioral and Respiratory Outcomes and the Development of Childhood Cancers.Toxicological sciences : an official journal of the Society of Toxicology · 2020Review
- Blood Pressure and Heart Rate Variability in Preschool Children Exposed to Smokeless Tobacco in Fetal Life.Journal of the American Heart Association · 2019Article
- Maternal Use of Snus in Pregnancy and Early Childhood Blood Pressure: A Warning for e-Cigarettes?Journal of the American Heart Association · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Maternal smoking during pregnancy has been associated with higher blood pressure and autonomic imbalance in the offspring. However, it has been difficult to determine the selective prenatal and postnatal contributions as children frequently have been exposed to smoking both before and after birth. The specific role of nicotine is also unclear. We aimed to determine whether exclusive prenatal exposure to nicotine from maternal use of smokeless tobacco (Swedish snus) in pregnancy was associated with blood pressure and autonomic heart rate control in their children. Methods and Results We measured oscillometric blood pressures in forty 5- to 6-year-old children with snus exposure in fetal life (n=21) and in tobacco-free controls (n=19). Taking the child's age and height into account, snus-exposed children had 4.2 (95% CI, 0.2-8.1) mm Hg higher systolic blood pressure than controls (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.