Evidence map›Paper›PMID 31615158›Full record

ArticleNutrients2019

Nutritional and Metabolic Characteristics of UK Adult Phenylketonuria Patients with Varying Dietary Adherence.

Benjamin Green, Robert Browne, Sarah Firman, Melanie Hill, Yusof Rahman, Kit Kaalund Hansen, Sarah Adam, Rachel Skeath, Paula Hallam, Ide Herlihy and 16 more

Registry-linked trialAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04969809 (Comparison of Atherogenic Risk Factors and Efficacy of Nutritional Treatment Among Adult Phenylketonuria Patients), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04969809 nanot yet recruitingnot on this mapstarted 2021, after this paper: background citation

Comparison of Atherogenic Risk Factors and Efficacy of Nutritional Treatment Among Adult Phenylketonuria Patients

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2021 to 2026Enrolled50ConditionsPhenylketonurias, Nutritional and Metabolic DiseasesArmsUltrasound of the jugular veins, addition of phenylalanine-free protein substitutes
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Phenylketonuria as an Adherence Disease.Patient preference and adherence · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. METABOLIC CONTROL AND BODY COMPOSITION OF CHILDREN AND ADOLESCENTS WITH PHENYLKETONURIA.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Benjamin GreenMedical Affairs, Nutricia Advanced Medical Nutrition, Wiltshire BA14 0XQ, UK. ben.green@nutricia.com.
Robert BrowneMedical Affairs, Nutricia Advanced Medical Nutrition, Wiltshire BA14 0XQ, UK. robert.browne@nutricia.com.
Sarah FirmanGuy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK. Sarah.Firman@gstt.nhs.uk.
Melanie HillSheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK. Melanie.Hill@sth.nhs.uk.
Yusof RahmanGuy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK. Yusof.Rahman@health.nsw.gov.au.
Kit Kaalund HansenUniversity College London Hospitals NHS Foundation Trust, London WC1N 3BG, UK. kit.kaalundhansen@nhs.net.
Sarah AdamRoyal Hospital for Children, Glasgow, Glasgow G51 4TF, UK. Sarah.Adam@ggc.scot.nhs.uk.
Rachel SkeathGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK. Rachel.Skeath@gosh.nhs.uk.
Paula HallamGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK. paula@tinytotsnutrition.co.uk.
Ide HerlihyGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK. Ide.Herlihy@gosh.nhs.uk.
Fiona JenkinsonRoyal Victoria Infirmary, Newcastle, Newcastle upon Tyne NE1 4LP, UK. Fiona.Jenkinson@nuth.nhs.uk.
Claire NicolRoyal Victoria Infirmary, Newcastle, Newcastle upon Tyne NE1 4LP, UK. Claire.Nicol@ggc.scot.nhs.uk.
Sandra AdamsRoyal Victoria Infirmary, Newcastle, Newcastle upon Tyne NE1 4LP, UK. Sandra.Adams@nuth.nhs.uk.
Lisa GaffCambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. lisa.gaff@addenbrookes.nhs.uk.
Sarah DonaldCambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. sarah.donald@addenbrookes.nhs.uk.
Charlotte DawsonQueen Elizabeth Hospital, Birmingham B15 2TH, UK. Charlotte.Dawson@uhb.nhs.uk.
Louise RobertsonQueen Elizabeth Hospital, Birmingham B15 2TH, UK. Louise.Robertson@uhb.nhs.uk.
Carla FitzacharyGuy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK. Carla.Fitzachary@gstt.nhs.uk.
Heidi ChanMedical Affairs, Nutricia Advanced Medical Nutrition, Wiltshire BA14 0XQ, UK. Heidi.chan@nutricia.com.
Arlene SlabbertGuy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK. Arlene.Slabbert@gstt.nhs.uk.
Carolyn DunlopRoyal Hospital for Sick Children, Edinburgh EH9 1LF, UK. Carolyn.Dunlop@nhslothian.scot.nhs.uk.
Alison CozensRoyal Hospital for Sick Children, Edinburgh EH9 1LF, UK. alison.cozens@nhs.net.
Camille NewbyBristol University Hospitals NHS Foundation Trust, Bristol BS1 3NU, UK. Camille.Newby@UHBristol.nhs.uk.
Victoria BittleBristol University Hospitals NHS Foundation Trust, Bristol BS1 3NU, UK. Victoria.Bittle@UHBristol.nhs.uk.
Gary HubbardMedical Affairs, Nutricia Advanced Medical Nutrition, Wiltshire BA14 0XQ, UK. gary.hubbard@nutricia.com.
Rebecca StrattonMedical Affairs, Nutricia Advanced Medical Nutrition, Wiltshire BA14 0XQ, UK. rebecca.stratton@nutricia.com.

Funding

Nutricia Ltd n/a
6 · The paper itself

Abstract

The nutritional and metabolic characteristics of adult phenylketonuria (PKU) patients in the UK with varying dietary adherence is unknown. In other countries, nutritional and metabolic abnormalities have been reported in nonadherent patients compared to adherent counterparts. A pooled analysis of primary baseline data from two UK multi-centre studies was therefore performed to establish whether this is true from a UK perspective. Adult PKU patients who had provided 3-day food records and amino acid blood samples were included and grouped according to dietary adherence (adherent;

Indexed as

Nutritional StatusAdolescentAdultAmino AcidsDietDietary SupplementsEnergy IntakeFemaleHumansMaleMicronutrientsPatient CompliancePhenylketonuriasUnited KingdomYoung AdultAmino AcidsMicronutrientsadherenceNonadherencenutrient intakePhenylalaninePhenylketonuriaPKU

Identifiers

PMID31615158
PMCPMC6835765

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.