Evidence map›Paper›PMID 31615108›Full record

ArticleCells2019

An RBPJ-

Bernd M Gahr, Franziska Brändle, Mirjam Zimmermann, Anja C Nagel

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bernd M GahrInstitute of Genetics (240), University of Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany.
Franziska BrändleInstitute of Genetics (240), University of Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany.
Mirjam ZimmermannInstitute of Genetics (240), University of Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany.
Anja C NagelInstitute of Genetics (240), University of Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany. anja.nagel@uni-hohenheim.de.
University of Hohenheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notch signaling activity governs widespread cellular differentiation in higher animals, including humans, and is involved in several congenital diseases and different forms of cancer. Notch signals are mediated by the transcriptional regulator RBPJ in a complex with activated Notch (NICD). Analysis of Notch pathway regulation in humans is hampered by a partial redundancy of the four Notch receptor copies, yet RBPJ is solitary, allowing its study in model systems. In

Indexed as

AllelesAnimalsAnimals, Genetically ModifiedDrosophila melanogasterDrosophila ProteinsHomozygoteImmunoglobulin J Recombination Signal Sequence-Binding ProteinMicePhenotypeProtein BindingProtein StabilityReceptors, NotchRepressor ProteinsSignal TransductionTranscription FactorsDrosophila ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinRbpj protein, mouseReceptors, NotchRepressor ProteinsSu(H) protein, DrosophilaTranscription FactorsDrosophilafunctional conservationmodel systemNotch signaling pathwayRBPJregulationSu(H)

Identifiers

PMID31615108
PMCPMC6829621
OpenAlexW2980219010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.