Evidence map›Paper›PMID 31615089›Full record

SynthesisCells2019

Clinical Theragnostic Relationship between Drug-Resistance Specific miRNA Expressions, Chemotherapeutic Resistance, and Sensitivity in Breast Cancer: A Systematic Review and Meta-Analysis.

Rama Jayaraj, Sankaranarayanan Gomathi Nayagam, Ananya Kar, Shubhangi Sathyakumar, Hina Mohammed, Maria Smiti, Shanthi Sabarimurugan, Chellan Kumarasamy, T Priyadharshini, K M Gothandam and 5 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. The emerging role and mechanism of HMGA2 in breast cancer.Journal of cancer research and clinical oncology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Research progress of exosomes in drug resistance of breast cancer.Frontiers in bioengineering and biotechnology · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rama JayarajCollege of Health and Human Sciences, Charles Darwin University, Darwin 0810, Australia. Rama.Jayaraj@cdu.edu.au.
Sankaranarayanan Gomathi NayagamSchool of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, India.
Ananya KarSchool of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, India.
Shubhangi SathyakumarSchool of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, India.
Hina MohammedSchool of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, India.
Maria SmitiSchool of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, India.
Shanthi SabarimuruganCHIRI, School of Pharmacy and Biomedical Research, Faculty of Health Sciences, Curtin University, Bently campus, Australia.
Chellan KumarasamyUniversity of Adelaide, North Terrace Campus, Adelaide 5005, Australia.
T PriyadharshiniDepartment of Biochemistry, Bharathiyar University, Coimbatore, Tamil Nadu 641046, India.
K M GothandamCollege of Health and Human Sciences, Charles Darwin University, Darwin 0810, Australia.
N RameshCollege of Health and Human Sciences, Charles Darwin University, Darwin 0810, Australia.
Ajay GuptaNational Heart Institute, New Delhi 110065, India.
Siddhartha BaxiJohn Flynn Private Hospital, Genesis Cancer Care, Tugun 4224, Australia.
Suja SwamiappanDepartment of Biochemistry, Bharathiyar University, Coimbatore, Tamil Nadu 641046, India.
Sunil KrishnanDepartment of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston TX 77030, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Awareness of breast cancer has been increasing due to early detection, but the advanced disease has limited treatment options. There has been growing evidence on the role of miRNAs involved in regulating the resistance in several cancers. We performed a comprehensive systematic review and meta-analysis on the role of miRNAs in influencing the chemoresistance and sensitivity of breast cancer. A bibliographic search was performed in PubMed and Science Direct based on the search strategy, and studies published until December 2018 were retrieved. The eligible studies were included based on the selection criteria, and a detailed systematic review and meta-analysis were performed based on PRISMA guidelines. A random-effects model was utilised to evaluate the combined effect size of the obtained hazard ratio and 95% confidence intervals from the eligible studies. Publication bias was assessed with Cochran's Q test, I

Indexed as

Biomarkers, PharmacologicalBiomarkers, TumorBreast NeoplasmsDrug Resistance, NeoplasmFemaleHumansMicroRNAsPrognosisTranscriptomeBiomarkers, PharmacologicalBiomarkers, TumorMicroRNAsbreast cancerchemoresistancemeta-analysismiRNAssystematic review

Identifiers

PMID31615089
PMCPMC6830093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.