Evidence map›Paper›PMID 31615042›Full record

ArticlePolymers2019

Cytocompatible and Antibacterial Properties of Chitosan-Siloxane Hybrid Spheres.

Yuki Shirosaki, Manato Nakatsukasa, Saki Yasutomi, Susana Cruz-Neves, Satoshi Hayakawa, Akiyoshi Osaka, Toshinari Maeda, Toshiki Miyazaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuki ShirosakiFaculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan. yukis@che.kyutech.ac.jp.ORCID 0000-0003-4207-4393
Manato NakatsukasaGraduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. en20746@s.okayama-u.ac.jp.
Saki YasutomiFaculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan. s-yasutomi@che.kyutech.ac.jp.
Susana Cruz-NevesGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0196, Japan. susanacruzneves@gmail.com.
Satoshi HayakawaGraduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. satoshi@cc.okayama-u.ac.jp.ORCID 0000-0002-1097-8614
Akiyoshi OsakaFaculty of Engineering, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. akiosaka@okayama-u.ac.jp.
Toshinari MaedaGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0196, Japan. toshi.maeda@life.kyutech.ac.jp.
Toshiki MiyazakiGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0196, Japan. tmiya@life.kyutech.ac.jp.

Funding

Ministry of Education, Culture, Sports, Science and Technology Kojinsenbatu
6 · The paper itself

Abstract

Microporous spheres in a hybrid system consisting of chitosan and γ-glycidoxypropyltrimethoxysilane (GPTMS) have advantages in a range of applications, e.g., as vehicles for cell transplantation and soft tissue defect filling materials, because of their excellent cytocompatibility with various cells. In this study, microporous chitosan-GPTMS spheres were prepared by dropping chitosan-GPTMS precursor sols, with or without a cerium chloride, into liquid nitrogen using a syringe pump. The droplets were then freeze dried to give the pores of size 10 to 50 μm. The cell culture tests showed that L929 fibroblast-like cells migrated into the micropores larger than 50 μm in diameter, whereas MG63 osteoblast-like cells proliferated well and covered the granule surfaces. The spheres with cerium chloride showed antibacterial properties against both gram-negative and gram-positive bacteria.

Indexed as

antibacterial propertycell behaviorcerium ionchitosan-siloxane hybridmicroporous spheres

Identifiers

PMID31615042
PMCPMC6835879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.