Evidence map›Paper›PMID 31614992›Full record

ReviewNutrients2019

Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss.

Corey A Rynders, Elizabeth A Thomas, Adnin Zaman, Zhaoxing Pan, Victoria A Catenacci, Edward L Melanson

5 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 161 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 19 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04502329 nacompletednot on this map

The Effect of Intermittent Fasting Diet on Metabolic Syndrome Biomarkers and Weight Management in Individuals With Metabolic Syndrome

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2019 to 2020Enrolled65ConditionsMetabolic SyndromeArmsDiet
NCT04526847 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effectiveness of Intermittent Fasting Compared to Continuous Energy Restriction on Body Weight Loss Among Overweight/Obese Adults: a Randomized Controlled Trial

TypeinterventionalSponsorArmed Police Force Hospital, NepalRan2023 to 2023Enrolled112ConditionsOverweight and ObesityArmsIntermittent energy restriction (IER) : 5:2 diet pattern, Continuous energy restricted (CER) group
NCT05456386 naunknown statusnot on this mapstarted 2022, after this paper: background citation

BioRhythm Health Coaching and Sleep Monitoring Program for Weight Loss

TypeinterventionalSponsorStephen HutchisonRan2022 to 2023Enrolled65ConditionsObesityArmsThe Circadian Rhythm Approach to Weight Loss (CRAWL)
NCT05590247 nacompletednot on this mapstarted 2022, after this paper: background citation

Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis

TypeinterventionalSponsorOhio State UniversityRan2022 to 2025Enrolled60ConditionsPsoriasis, Psoriatic ArthritisArmsIntermittent Fasting Diet
NCT06139562 nacompletednot on this map

Two Different Dietary Approaches In Body Composition And Serum Hormone Levels: Time-Restricted And Extended Feeding

TypeinterventionalSponsorBaskent UniversityRan2019 to 2020Enrolled20ConditionsTime Restricted Feeding, ObesityArmsTime-Restricted Feeding, Extended-Time Feeding
3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 19 syntheses or guidelines pooled it, 330 citations in OpenAlex.

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  6. Guideline
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  16. Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021
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  20. Effect of Time-Restricted Eating on Metabolic Adaptation in Adults With Severe Obesity During Early Phase of Weight Loss.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Trial

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Corey A RyndersDepartment of Medicine, Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. corey.rynders@cuanschutz.edu.
Elizabeth A ThomasDepartment of Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. elizabeth.thomas@cuanschutz.edu.
Adnin ZamanDepartment of Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. adnin.zaman@cuanschutz.edu.
Zhaoxing PanDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. zhaoxing.pan@cuanschutz.edu.
Victoria A CatenacciDepartment of Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. vicki.catenacci@cuanschutz.edu.
Edward L MelansonDepartment of Medicine, Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. ed.melanson@cuanschutz.edu.ORCID 0000-0001-9151-9745
University of Colorado Anschutz Medical Campus · USGeriatric Research Education and Clinical Center · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Institutional Career Development CoreKL2TR002534 · NCATS · UNIVERSITY OF COLORADO DENVER · PI BURNHAM, ELLEN L · 2018 to 2022
$4.6M
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized TrialR01DK111622 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CATENACCI, VICTORIA A · 2017 to 2021
$4.4M
Adaptive responses to overfeeding and weight regain in reduced obese individualsR01DK114272 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BESSESEN, DANIEL HOLLAND · 2018 to 2022
$2.5M
Time restricted feeding and metabolic rhythms in humansK01DK113063 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI RYNDERS, COREY ALLAN · 2017 to 2021
$832k
Time Restricted Feeding as a Weight Loss Intervention in Overweight and Obese AdultsR21DK117499 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CORNIER, MARC-ANDRE, THOMAS, ELIZABETH ANNE · 2019 to 2020
$428k
NCATS NIH HHS KL2 TR002534NCATS NIH HHS UL1 TR002535NIDDK NIH HHS K01 DK113063NIDDK NIH HHS P30 DK048520NIH HHS K01 DK113063NIH HHS KL2 TR002534NIH HHS P30 DK048520NIH HHS R01 DK111622NIH HHS R01 DK114272NIH HHS R21 DK117499NIH HHS UL1 TR002535U.S. Department of Veterans Affairs Eastern Colorado VA Geriatric Research, Education, and Clinical Center
6 · The paper itself

Abstract

The current obesity epidemic is staggering in terms of its magnitude and public health impact. Current guidelines recommend continuous energy restriction (CER) along with a comprehensive lifestyle intervention as the cornerstone of obesity treatment, yet this approach produces modest weight loss on average. Recently, there has been increased interest in identifying alternative dietary weight loss strategies that involve restricting energy intake to certain periods of the day or prolonging the fasting interval between meals (i.e., intermittent energy restriction, IER). These strategies include intermittent fasting (IMF; >60% energy restriction on 2-3 days per week, or on alternate days) and time-restricted feeding (TRF; limiting the daily period of food intake to 8-10 h or less on most days of the week). Here, we summarize the current evidence for IER regimens as treatments for overweight and obesity. Specifically, we review randomized trials of ≥8 weeks in duration performed in adults with overweight or obesity (BMI ≥ 25 kg/m

Indexed as

Caloric RestrictionFastingMealsWeight LossHumansTime Factorsalternate day fastingmeal timingobesityweight loss

Identifiers

PMID31614992
PMCPMC6836017
OpenAlexW2979922699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.