Evidence map›Paper›PMID 31614941›Full record

ArticleCells2019

The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells.

Rebecca M Parodi-Rullán, Xavier Chapa-Dubocq, Roberto Guzmán-Hernández, Sehwan Jang, Carlos A Torres-Ramos, Sylvette Ayala-Peña, Sabzali Javadov

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Review
  9. A 20/20 view of ANT function in mitochondrial biology and necrotic cell death.Journal of molecular and cellular cardiology · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rebecca M Parodi-RullánDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. rebecca.parodi-rullan@temple.edu.
Xavier Chapa-DubocqDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. xavier.chapa@upr.edu.
Roberto Guzmán-HernándezDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. roberto.guzman7@upr.edu.
Sehwan JangDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. sehwan.jang@upr.edu.ORCID 0000-0003-4426-537X
Carlos A Torres-RamosDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. carlos.torres27@upr.edu.
Sylvette Ayala-PeñaDepartment of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. sylvette.ayala@upr.edu.
Sabzali JavadovDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA. sabzali.javadov@upr.edu.ORCID 0000-0002-7024-5383
University of Puerto Rico System · PR

Funding

RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
Role of Ape1 in Huntington's Disease NeurodegenerationSC1NS095380 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI AYALA-PENA, SYLVETTE · 2015 to 2019
$1.6M
Crosstalk between mitochondrial permeability transition and ETC supercomplexes in myocardial infarctionSC1GM128210 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JAVADOV, SABZALI · 2017 to 2019
$1.1M
NIGMS NIH HHS R25 GM061838NIGMS NIH HHS SC1 GM128210NINDS NIH HHS SC1 NS095380
6 · The paper itself

Abstract

Individual electron transport chain complexes have been shown to assemble into the supramolecular structures known as the respiratory chain supercomplexes (RCS). Several studies reported an associative link between RCS disintegration and human diseases, although the physiological role, structural integrity, and mechanisms of RCS formation remain unknown. Our previous studies suggested that the adenine nucleotide translocase (ANT), the most abundant protein of the inner mitochondrial membrane, can be involved in RCS assembly. In this study, we sought to elucidate whether

Indexed as

AnimalsCell LineElectron TransportElectron Transport Complex IGene Knockdown TechniquesMaleMembrane Potential, MitochondrialMiceMitochondria, HeartMitochondrial ADP, ATP TranslocasesMitochondrial MembranesMyocytes, CardiacRatsReactive Oxygen SpeciesElectron Transport Complex IMitochondrial ADP, ATP TranslocasesReactive Oxygen Speciesadenine nucleotide translocaseETC complexesH9c2 cardiomyoblastsmitochondriarespiratory supercomplexes

Identifiers

PMID31614941
PMCPMC6829619
OpenAlexW2979961119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.