Evidence map›Paper›PMID 31614887›Full record

ArticlePathogens (Basel, Switzerland)2019

Inactivation of Zika Virus by Photoactive Iodonaphthyl Azide Preserves Immunogenic Potential of the Virus.

Amy L Austin, Bianca Galasso, Caitlin Nickens, Barbara Knollmann-Ritschel, Anuj Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amy L AustinDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20853, USA. amy.l.austin20.mil@mail.mil.
Bianca GalassoDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20853, USA. bianca.galasso.ctr@usuhs.edu.
Caitlin NickensDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20853, USA. caitlin.m.nickens.mil@mail.mil.
Barbara Knollmann-RitschelDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20853, USA. barbara.knollmann-ritschel@usuhs.edu.
Anuj SharmaDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20853, USA. anuj.sharma.ctr@usuhs.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus's (ZIKV) emergence as a pathogen of significant public health importance has accelerated efforts to develop a ZIKV vaccine. To date, the need for an effective ZIKV vaccine is unmet. In this study, we report inactivation of ZIKV using a hydrophobic photoactive compound: 1, 5 iodonaphthyl azide (INA). 50 and 100 µM of INA completely inactivated ZIKV (INA-ZIKV). Western blot and ELISA analysis show some loss of the binding capacity of INA-iZIKV to anti-ZIKV monoclonal antibodies; however, immunization of mice with INA-iZIKV demonstrated seroconversion and ZIKV-neutralizing antibody response. RNA isolated from INA-iZIKV did not induce productive infection in Vero cells, suggesting inactivation of ZIKV RNA. These results suggest that in the absence of an approved ZIKV vaccine, INA-iZIKV can be pursued as a viable ZIKV vaccine candidate.

Indexed as

immunizationinactivationiodonaphthyl azidevaccineZika virus

Identifiers

PMID31614887
PMCPMC6963691

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.