Evidence map›Paper›PMID 31614708›Full record

ArticleInternational journal of molecular sciences2019

Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing

Hanfang Cai, Chaoqun Zhu, Zhilong Chen, Rexiati Maimaiti, Mingming Sun, Richard J McCormick, Xianyong Lan, Hong Chen, Wei Guo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. RBM20, a Therapeutic Target to Alleviate Myocardial StiffnessFrontiers in cardiovascular medicine · 2022
    Review
  5. Article
  6. Article
  7. New Insights in RBM20 Cardiomyopathy.Current heart failure reports · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hanfang CaiDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. caihanfang.cool@163.com.
Chaoqun ZhuDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. czhu1@uwyo.edu.
Zhilong ChenDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. zhilongchen@sina.com.
Rexiati MaimaitiDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. rmaimait@uwyo.edu.ORCID 0000-0001-6751-2113
Mingming SunDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. msun2@uwyo.edu.
Richard J McCormickDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. RMcCrmck@uwyo.edu.
Xianyong LanCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. lan342@126.com.
Hong ChenCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. chenhong1955@nwafu.edu.cn.
Wei GuoDepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USA. wguo3@uwyo.edu.
University of Wyoming · USNorthwest A&F University · CN

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Robert Scott Seville · 2012 to 2026
$56.8M
American Heart Association 16BGIA27790136American Heart Association 19TPA3480072American Heart Association-American Stroke Association 16BGIA27790136American Heart Association-American Stroke Association 19TPA34830072National Institute of Food and Agriculture 1009266NIGMS NIH HHS NIGMSP20GM103432NIGMS NIH HHS P20 GM103432
6 · The paper itself

Abstract

RNA binding motif 20 (RBM20) is a key regulator of pre-mRNA splicing of titin and other genes that are associated with cardiac diseases. Hormones, like insulin, triiodothyronine (T3), and angiotensin II (Ang II), can regulate gene-splicing through RBM20, but the detailed mechanism remains unclear. This study was aimed at investigating the signaling mechanism by which hormones regulate pre-mRNA splicing through RBM20. We first examined the role of RBM20 in Z-, I-, and M-band titin splicing at different ages in wild type (WT) and

Indexed as

MAP Kinase Signaling SystemRNA SplicingAngiotensin IIAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, Culturedets-Domain Protein Elk-1Intracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle ProteinsMyocytes, CardiacRatsRats, Sprague-DawleyRNA-Binding ProteinsRNA, MessengerAngiotensin IICalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2g protein, ratElk1 protein, ratets-Domain Protein Elk-1Intracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle ProteinsRBM20 protein, ratRNA-Binding ProteinsRNA, MessengerTrdn protein, ratangiotensin IIhormonesinsulinpre-mRNA splicingRBM20T3

Identifiers

PMID31614708
PMCPMC6829565
OpenAlexW2980123655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.