Evidence map›Paper›PMID 31614591›Full record

ArticleMicromachines2019

A New Self-Activated Micropumping Mechanism Capable of Continuous-Flow and Real-Time PCR Amplification Inside 3D Spiral Microreactor.

Kangning Wang, Di Wu, Wenming Wu

Abstract read
In one paragraph

Article in Micromachines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kangning WangChangchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Beijing 100864, China. 15098139057@163.com.
Di WuChangchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Beijing 100864, China. wudi16@mails.ucas.ac.cn.ORCID 0000-0002-0245-8205
Wenming WuChangchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Beijing 100864, China. wuwm@ciomp.ac.cn.ORCID 0000-0003-4793-6132

Funding

National Natural Science Foundation of China No. 61704169Natural Science Foundation of Jilin Province 20180520112JH
6 · The paper itself

Abstract

A self-activated micropump which is capable of stable velocity transport for a liquid to flow a given distance inside a 3D microchannel has been a dream of microfluidic scientists for a long time. A new self-activated pumping mechanism has been proposed in this paper. It is different from the authors' previous research which relied on the fluid resistance of a quartz capillary tube or end-blocked gas-permeable silicone or a polydimethylsiloxane (PDMS) wall to automate the flow. In this research, an end-open stretched Teflon tube was utilized for passive transport for the first time. A new fluid transmission mode was adopted with the assistance of a cheaper easily accessible oil mixture to achieve stable continuous flow. Finally, this novel micropump has been applied to real-time continuous-flow polymerase chain reactions (PCRs), with an amplification efficiency similar to that of a commercial PCR cycler instrument.

Indexed as

continuous flowmicrofluidicsreal-time PCRviscosity

Identifiers

PMID31614591
PMCPMC6843785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.