Evidence map›Paper›PMID 31614494›Full record

ArticleInternational journal of molecular sciences2019

Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells.

Sonja Häckel, Mona Zolfaghar, Jie Du, Sven Hoppe, Lorin M Benneker, Nathalie Garstka, Marianna Peroglio, Mauro Alini, Sibylle Grad, Avner Yayon and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Orthobiologic Management Options for Degenerative Disc Disease.Bioengineering (Basel, Switzerland) · 2024
    Review
  4. Article
  5. Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sonja HäckelAO Research Institute Davos, 7270 Davos, Switzerland. sonja.haeckel@insel.ch.ORCID 0000-0002-9415-6633
Mona ZolfagharAO Research Institute Davos, 7270 Davos, Switzerland. mona_zolfaghar@yahoo.com.
Jie DuAO Research Institute Davos, 7270 Davos, Switzerland. du.jie@aofoundation.org.
Sven HoppeDepartment of Orthopaedic, Inselspital Bern, 3010 Bern, Switzerland. Sven.Hoppe@insel.ch.
Lorin M BennekerDepartment of Orthopaedic, Inselspital Bern, 3010 Bern, Switzerland. lorin.benneker@insel.ch.
Nathalie GarstkaUniversitätsklinik Wien, 1090 Vienna, Austria. nathalie.garstka@meduniwien.ac.at.
Marianna PeroglioAO Research Institute Davos, 7270 Davos, Switzerland. marianna.peroglio@aofoundation.org.
Mauro AliniAO Research Institute Davos, 7270 Davos, Switzerland. mauro.alini@aofoundation.org.
Sibylle GradAO Research Institute Davos, 7270 Davos, Switzerland. sibylle.grad@aofoundation.org.
Avner YayonProCore Ltd. Weizmann Science Park, 76400 Ness Ziona, Israel. yayon@procore-bio.com.
Zhen LiAO Research Institute Davos, 7270 Davos, Switzerland. zhen.li@aofoundation.org.ORCID 0000-0002-9754-6389
AO Foundation · CHUniversity Hospital of Bern · CHUniversitätszahnklinik Wien · AT

Funding

AO Foundation DiscregenAOSpine IVDAFRHorizon 2020 642414National Natural Science Foundation of China 51873069National Natural Science Foundation of China 81772333
6 · The paper itself

Abstract

We investigated the effects of a fibrin-hyaluronic acid hydrogel (FBG-HA) and fibroblast growth factor 18 (FGF-18) for nucleus pulposus (NP) regeneration. Healthy bovine (

Indexed as

AnimalsBiomimeticsCarbonic AnhydrasesCattleCell Culture TechniquesCells, CulturedCollagen Type IIFibroblast Growth FactorsGlycosaminoglycansHumansHyaluronic AcidHydrogelsNucleus PulposusPhenotypeRegenerationCarbonic Anhydrasescarbonic anhydrase XIICollagen Type IIfibroblast growth factor 18Fibroblast Growth FactorsGlycosaminoglycansHyaluronic AcidHydrogelsfibrin-hyaluronic acid hydrogelfibroblast growth factor 18nucleus pulposus cells

Identifiers

PMID31614494
PMCPMC6834142
OpenAlexW2980257806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.